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Volume 7, Issue 3 (Suppl) J Nutr Disorders Ther, an open access journal
ISSN: 2161-0509
Page 97
JOINT EVENT
&
July 27-29, 2017 Rome, Italy
Advances in Natural Medicines Nutraceuticals & Neurocognition
14th International Conference on Clinical Nutrition
13th International Congress on
K36, a synthetic caffeamide derivative, improves the pathology of Alzheimer’s disease in high-fat-diet
plus streptozotocin-induced hyperinsulinemic and hyperglycemic rats
Pei-Chin Wu1, Meng-Shiuan Tu1, Rong-Shiuan Tu1, Shih-Shiang Lin1, Yeuh-Hsiung Kuo2, Wen-Chang Chang3, Yu-Wen Ting3, James Swi-Bea Wu3 and
Szu-Chuan Shen1
1National Taiwan Normal University, Taiwan
2China Medical University, Taiwan
3National Taiwan University, Taiwan
Type 2 Diabetes Mellitus (T2DM), major caused by obesity and characterized with insulin resistance, is a metabolic disease
commonly accompanied with hyperglycemia and hyperinsulinemia. Epidemiology studies have showed that T2DM is
a risk factor of Alzheimer’s disease (AD). Previous studies confirmed that caffeamide improves serum glucose and insulin
resistance in diabetic animal model. This study aims to investigate the protective effect of caffeamide derivative compound
K36 on pathology of AD in the high-fat-diet (HFD)-streptozotocin (STZ)-induced hyperglycemic and hyperinsulinemic rats.
The male Wistar rats were fed with High Fat Diet (60% fat of calorie) for 4 weeks were intra-peritoneally (i.p.) injected with
STZ (30 mg/kg b.w.) and then served HFD continuously for 8 weeks to induce hyperglycemia (mean serum glucose 224 mg/
dL) and hyperinsulinemia (mean serum insulin 0.35 ug/ml). The HFD-STZ rats were then orally administered with K36
(15 mg/kg b.w.) once a day for 13 weeks. The Morris Water Maze trial was performed for evaluating the improvement of
cognitive impairment before rats were sacrificed. The blood biochemical analysis was conducted after the rats were sacrificed.
The expressions of hippocampus and cortex insulin signaling and synaptic function related proteins were analyzed by Western
blotting. The rats exhibit hyperglycemia and hyperinsulinemia after HFD and STZ induction. The serum total cholesterol
(TG) and serum triglyceride (TC) decreased by 37% and 36%, respectively, in K36 treated HFD-STZ rats compared to the
HFD-STZ rats (p<0.05). The results fromMorris Water Maze suggested that K36 significantly improved the cognitive ability in
HFD-STZ rats (p<0.05). Western blotting assay revealed that the protein expression of cerebral insulin receptor (IR), phospho-
cAMP response element-binding protein (pCREB), brain-derived neurotrophic factor (BDNF), postsynaptic density protein
95 (PSD-95) in K36 treated HFD-STZ rats were significantly increased compared to the HFD-STZ rats (p<0.05). In addition,
K36 also suppressed the expression of brain amyloid precursor protein (APP) in HFD-STZ rats. According to the above results,
we suggest that K36 may prevent AD progression via alleviating cerebral insulin resistance and ameliorating synaptic plasticity
in HFD-STZ-induced hyperglycemic and hyperinsulinemic rats.
Micronutrient status of pregnant women in Pakistan and its relation to perinatal complications and
pregnancy outcomes
Sehar Iqbal
Medical University Vienna, Austria
Pregnancy is not solely the utmost imperative stage for both the mother and the child, but rather for the society as well, and
to phase an appropriate nutrition in terms of micronutrients holds a decisive power for avoiding any serious complications
or other way around. In order to study that impact, this study will focus on Pakistan, which is one of the low income countries,
and is confronting various public health challenges such as; an increase in the rate of MMR and IMR with every coming year.
The present study, therefore, has been designed to address this domain in a public health perspective. It will be conducted with
the obtained blood samples of 80 pregnant and 40 non-pregnant age matched women from a mono-centric hospital to compare
the status of iron, iodine, zinc, selenium and manganese in both groups. Furthermore, the birth defects like neonatal mortality,
low birth weight, the risk for preterm birth would also be recorded to elucidate the adverse consequences of malnutrition on
perinatal complications and pregnancy outcomes.
J Nutr Disorders Ther 2017, 7:3(Suppl)
DOI: 10.4172/2161-0509-C1-007