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Volume 7, Issue 3 (Suppl) J Nutr Disorders Ther, an open access journal
ISSN: 2161-0509
Page 89
JOINT EVENT
&
July 27-29, 2017 Rome, Italy
Advances in Natural Medicines Nutraceuticals & Neurocognition
14th International Conference on Clinical Nutrition
13th International Congress on
Maternal obesity and redox status: correlation between plasma leptin and oxidative erythrocytic
biomarkers
Nassima Malti1, Hafida Merzouk1, Reda Bettioui1, Meriem Saker 1 and Loubna Bouhmama2
1University of Tlemcen, Algeria
2University-Hospital Centre of Tlemcen, Algeria
Obesity is considered a risk factor during pregnancy and influences the development of obesity and its complications in
adulthood during pregnancy (maternal, fetal or placental). Besides eating disorders and obstetric complications, obese
mothers have a high incidence of oxidative disorders. Oxidative stress, characterized by an increase in free radical activity and
a reduction in antioxidant defenses, is a common feature between metabolic and physiological disorders of obesity and those of
pregnancy. It becomes a very important risk factor to consider in obese pregnant women. In addition, obesity is associated with
an inflammatory state characterized by hyperleptinemia which plays a major role in the pathophysiology of insulin resistance.
Leptin inhibits insulin secretion in the β-cell; there is a feedback loop, called the adipo-insular axis, where insulin increases the
secretion of leptin which, in response, inhibits insulin secretion. A possible leptino-resistance, in which the loop is disturbed,
would be responsible for hyperleptinemia and hyperinsulinemia observed in diabetes. The aim of this study is to evaluate the
correlation between maternal leptin and some markers of erythrocyte oxidative status (nitric oxide, superoxide anion, malon
di aldehyde, carbonylated proteins) during pre-gestational obesity. This work is part of a study on the assessment of redox
status during maternal obesity and its alterations on foeto-placental unit.
Biography
Nassima Malti is a Researcher at Laboratory of Physiology and Biochemistry of Nutrition, Department of Biology, Faculty of Sciences, University of Tlemcen. She
has completed her PhD in 2014.
Nassima Malti et al., J Nutr Disorders Ther 2017, 7:3(Suppl)
DOI: 10.4172/2161-0509-C1-007