nutraceuticals-clinical-nutrition-2017-posters-abstracts

32 / 33

conferenceseries.com
Volume 7, Issue 3 (Suppl) J Nutr Disorders Ther, an open access journal
ISSN: 2161-0509
Page 96
JOINT EVENT
&
July 27-29, 2017 Rome, Italy
Advances in Natural Medicines Nutraceuticals & Neurocognition
14th International Conference on Clinical Nutrition
13th International Congress on
Alpha lipoic acid alleviates hyperlipidemia, and inflammation of visceral adipose tissue in high-fat-diet
plus STZ-treated rat model
Meng-Shiuan Tu1, Pei-Chin Wu1, Rong-Shiuan Tu1, Shih-Shiang Lin1, Wen-Chang Chang2, Yu-Wen Ting2, James Swi-Bea Wu2 and Szu-Chuan Shen2
1National Taiwan Normal University, Taiwan
2National Taiwan University, Taiwan
Statement of the Problem: Hyperlipidemia is a symptom commonly occurring in type 2 diabetes mellitus (T2DM). Studies
suggest that individuals with both T2DM and hyperlipidemia may increase the risk of cardiovascular disease (CVD)-related
complications, such as coronary artery disease. The dysfunction of visceral adipose tissue (VAT) is considered to be associated
with insulin resistance and subsequently results in the lipid metabolism abnormality in T2DM. Evidence indicates that
inflammatory related markers such as tumor necrosis factor-alpha (TNF-a), interleukin 6 (IL-6) and nuclear factor kappa-β
are associated with the serum lipid level. Alpha lipoic acid (ALA) is an endogenous cofactor located in mitochondria. Previous
studies reported that ALA has therapy potential on hypoglycemia in diabetic rats. This study further investigates the effect of
ALA on hyperlipidemia in high-fat-diet plus STZ-induced hyperinsulinemic rats.
Methodology &Theoretical Orientation: MaleWistar rats were fed high fat diet (HFD, 60% fat of calorie) for 4 weeks followed
by single intra-peritoneal injection of Streptozotocin (STZ, 30mg kg-1) and then served HFD continuously for 8 weeks to
induce hyperinsulinemia. These HFD-STZ-induced hyperinsulinemic rats were orally administered with ALA once a day at a
dosage of 200 mg kg-1 for 13 weeks. After rats were sacrificed, the serum lipid profiles were measured, the VAT (epididymal
and perirenal adipose tissues) was picked up and weighed, and the pro-inflammation related cytokines of VAT were analyzed.
Findings: Our results showed that HFD plus STZ treatment results in hyperinsulinemia (1.53 µg mL-1) in rats. The
administration of ALA significantly reduced the levels of fasting serum insulin, total cholesterol (TC), low density lipoprotein
(LDL), triglyceride (TG) and free fatty acid (FFA) by 55%, 39%, 73%, 68% and 53%, respectively, whereas significantly
increased high density lipoprotein (HDL) level by 1.54 fold in hyperinsulinemic rats (p<0.05), suggesting the reduction on
the risk of CVD-related complications. The relative VAT weights were significantly decreased by 40% (p<0.05) in ALA treated
hyperinsulinemic rats (p<0.05), indicating the suppression of lipid accumulation. Moreover, ALA also significantly decreased
the levels of pro-inflammatory cytokines such as IL-6, TNF-a in serum and IL-1β in VAT of hyperinsulinemic rats (p<0.05).
Conclusion & Significance: In conclusion, the present study demonstrates that ALA may have benefits on preventing
the progression of hyperlipidemia via ameliorating blood lipid profiles and inflammation of VAT in HFD-STZ-induced
hyperinsulinemic rats.
J Nutr Disorders Ther 2017, 7:3(Suppl)
DOI: 10.4172/2161-0509-C1-007
Epidemiology and risk factor for hyperlipidemia in Pakistan
Muhammad Akram
GC University, Pakistan
Hyperlipidemia is very big health issue worldwide. Prevalence of hyperlipidemia is increasing in developed as well as
developing countries. Hyperlipidemia incidence and prevalence is increasing in Pakistan due to change in the lifestyle
of the Pakistani people. Hyperlipidemia is a major risk factor for cardiovascular disorders. Cardiovascular disorders are the
leading cause of death in Pakistan. Hyperlipidemia has high mortality and morbidly because it is the major risk factor for
developing stroke and cardiovascular disorders. Hyperlipidemia is very common in upper class society due to resting lifestyle
and lack of exercise. This study aims to provide awareness about hyperlipidemia as well as an updated knowledge about the
epidemiology and risk factor of hyperlipidemia in Pakistan.