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Volume 7, Issue 3 (Suppl)
J Nutr Disorders Ther, an open access journal
ISSN: 2161-0509
Page 94
JOINT EVENT
&
July 27-29, 2017 Rome, Italy
Advances in Natural Medicines Nutraceuticals & Neurocognition
14
th
International Conference on Clinical Nutrition
13
th
International Congress on
Detox and metabolism practical orthomolecular and nutritional approach
Roni Moya
CESPU University, Portugal
O
ne of the main health problems of the contemporary life and a mandatory concern to all antiaging physicians is the
outcome of the constant contact with the high level of intoxication, which can be connected to the wide range of diseases,
from allergies till cancer or neural degeneration. Discussion of the physiological pathways for detoxification has been mainly
centered on phase I and phase II enzyme systems. Some key nutrients and antioxidants substances, which can inhibit the
oxidation of a molecule and have the capacity to nullify the ill effects of oxidation caused by free radicals in the living organisms,
have been and continue to be investigated for their role in the modulation of metabolic pathways involved in detoxification
processes. Superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase are the key enzymatic antioxidants of this
defense system by which the free radicals that are produced during metabolic reactions are removed. Several publications to
date have leveraged cell, animal, and clinical studies to demonstrate that within the correct dose and synergy, food-derived
components and nutrients can function as important co-factors to modulate processes of conversion and excretion of toxins
from the body. The “Phase I” Cytochrome P450 CYP450 superfamily of enzymes is generally the first defense employed by
the body to bio transform xenobiotic, steroid hormones, and pharmaceuticals. This microsomal membrane bound, heme-
thiolate proteins, located mainly in the liver, but also in enterocytes, kidneys, lung, and even the brain, are responsible for the
oxidation, peroxidation, and reduction of several endogenous and exogenous substrates. It is accepted that any variability in
the number of CYP450 enzymes could have benefit(s) and/or consequence(s) for how an individual responds to the effect(s)
of (a) toxin(s). Many nutrients appear to act as both inducers and inhibitors of CYP1 enzyme. These findings indicate that
specific foods, vitamins, minerals, enzymes, etc., may upregulate or favorably balance metabolic pathways to assist with toxin
biotransformation and subsequent elimination. Various foods such as cruciferous vegetables, berries, soy, garlic, turmeric
and other spices, plus probiotics and exogenous antioxidants such as vitamins C, E, B complex, glutathione, cysteine,
taurine, methionine, L-carnitine, CoQ10, etc., have been suggested to be beneficial and commonly prescribed as part of the
orthomolecular and functional medicine based therapies. The objective of this talk is to highlight the clinical effect of the
orthomolecular nutrients in the DE intoxication mechanisms. Enhance the knowledge about the main antioxidants, foods and
their individual phytonutrients, especially in the case of dietary supplements and functional foods, could be worthwhile for
clinicians to consider for patients who are taking a polypharmacy approach or are in contact with pollution by-products, heavy
metals, hormones and further xenobiotic.
ronimoya@gmail.comJ Nutr Disorders Ther 2017, 7:3(Suppl)
DOI: 10.4172/2161-0509-C1-007
Prevalence of obesity and its association with diet among 13-year old Omani school children
Halima Nasser Hareth Al Dhali
Sultan Qaboos University, Oman
O
besity is a global health disorder and theWHO considers obesity as themost serious non-communicable disease worldwide
and is closely related to improper diet. All age groups are affected but the problem becomes worse when children are
affected. Obesity in children is defined as BMI > 95th percentile as defined in the Expert Committee Recommendations. In the
US, childhood obesity is about 11%, overweight is about 25%. Obesity prevalence worldwide is on the rise since 1970 especially
in developed countries. A WHO report stated that, approximately 58% of diabetes mellitus, 21% of ischemic heart disease and
8–42% of cancer globally were attributable to obesity. These diseases can affect children and adolescents. Obesity also increase
cardiovascular disease and increases the risks of all-cause mortality. Obese children are also more likely to become overweight
in adulthood than are lean children. Approximately one half of overweight adolescents and over one-third of overweight
children remain obese in adulthood.
u098181@student.squ.edu.om