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conferenceseries.com
October 20-22, 2016 Rome, Italy
11th International Conference and Expo on
Nanoscience and Molecular Nanotechnology
Volume 7, Issue 5 (Suppl) J Nanomed Nanotechnol 2016
ISSN: 2157-7439 JNMNT an open access journal NanoScience 2016
October 20-22, 2016
Facile encapsulation of gold nanoparticles into PLGA nanocarriers: Toward visualizing polymeric
nanoparticles inside biological compartments
Alaaldin M Alkilany1, Ji E Park2, Jonathan R Eller2 and Catherine J Murphy 2
1University of Jordan, Jordan
2University of Illinois at Urbana-Champaign, USA
Polymeric nanoparticles are promising candidates as a selective drug delivery platform with tremendous number of biomedical
applications. PLGA, poly(lactic-co-glycolic acid), is the most used polymer to prepare polymeric nanoparticles due to its well
documented safety and biodegradability, high drug loading, ease of synthesis and being commercially available at reasonable cost.
However, the fate of PLGA nanocarriers (PLGA-NCs), as well as other polymeric nanoparticles, in biological compartments is
poorly understood. Available labelling approaches with fluorescent agents suffer from serious drawbacks such as photobleaching
and desorption of the conjugated flourophores from nanoparticles. Herein, we report on loading PLGA-NCs with gold nanoparticles
(GNPs) that serve as a probe for quantification and visualization of the hosting PLGA-NCs. In this contribution, we describe a facile
method to encapsulate GNPs efficiently into PLGA-NCs. Moreover, we describe an interesting trend where the type of the capping
agent on GNPs plays a crucial role in controlling the encapsulation efficiency into PLGA nanomatrix. Finally, we show preliminary
results on visualizing “transparent” PLGA nanocarriers inside cancer cells using encapsulated GNPs as probes.
Biography
Alaaldin M Alkilany obtained his PhD at the University of Illinois Urbana-Champaign, USA (under the supervision of Professor Catherine Murphy). Afterward, he
joined the Georgia Regents University (USA) as a Post-doctoral research fellow and then the University of Jordan as an Assistant Professor of Pharmaceutics and
Pharmaceutical Technology in the Faculty of Pharmacy (Jordan). His research focuses on understanding the nano-bio interface toward desighning effective and
safe nanotherapeutics. He has published more than 25 papers in reputed journals.
Alaaldin M Alkilany et al., J Nanomed Nanotechnol 2016, 7:5 (Suppl)