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conferenceseries.com
October 20-22, 2016 Rome, Italy
11th International Conference and Expo on
Nanoscience and Molecular Nanotechnology
Volume 7, Issue 5 (Suppl) J Nanomed Nanotechnol 2016
ISSN: 2157-7439 JNMNT an open access journal NanoScience 2016
October 20-22, 2016
Poly-dopamine coated nano-size liposomes as novel drug carriers
Wei Zong
Harbin Institute of Technology, China
We report the stimuli-responsive poly-dopamine protected liposomes (liposome@PDA) drug carriers. The novel drug carriers
are pH sensitive drug delivery systems. 5-fluorouracil (5-FU) which is the typical chemotherapeutic agent was loaded into the
nano-size liposome@PDA capsules. The release percentages of 5-FU are 2.9%, 23.7%, 48.4%, 77.2% in the solution with pH 7.42, 6.87,
4.11 and 3.16, respectively. The in vitro cell cytotoxicity experiment showed that the capsules presented positive cell viability (above
90%). The capsule can easily pass the cell membranes and then up taken by the cells, thus leading to inhibition of cancer cell activity.
The drug-loaded capsules performed better than free drug. Our finding demonstrates the great potential of liposome@PDA capsules
as carriers in biomedical applications.
Biography
Wei Zong has completed her Master’s from Harbin Institute of Technology University. She is a PhD candidate in Harbin Institute of Technology University now.
Wei Zong, J Nanomed Nanotechnol 2016, 7:5 (Suppl)