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conferenceseries.com
October 20-22, 2016 Rome, Italy
11th International Conference and Expo on
Nanoscience and Molecular Nanotechnology
Volume 7, Issue 5 (Suppl) J Nanomed Nanotechnol 2016
ISSN: 2157-7439 JNMNT an open access journal NanoScience 2016
October 20-22, 2016
Hierarchical release of liposomes with aqueous two phase system: A new strategy for long circulating
liposomes
Xunan Zhang
Harbin Institution of Technology, China
We discovered the unique release behavior of aqueous two phase system (ATPS) within liposomes, which might pave new
revenue for long-circulating liposomes. ATPS is composed of PEG and dextran. The unique release behavior is based on the
disproportional distribution of DOX in each polymer phase. The release time was prolonged 3 h more than regular liposomes. Lipid
vesicles were fabricated by electro-formation and extrusion methods. Furthermore, cytotoxicity and localization in HeLa cells of
nanoscale vesicles were estimated. The inhibition rate was twice than pure drug.
Biography
Xunan Zhang is pursuing his PhD at Harbin Institute of Technology. He is a Member of Professor Xiaojun Han’s group which has published more than 40 papers in
the fields of artificial cell membranes, controlled drug release, biosensors and microfluidics since established, in 2012.
Xunan Zhang, J Nanomed Nanotechnol 2016, 7:5 (Suppl)