nano-congress-2016_posters-accepted-abstracts

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Volume 7, Issue 4(Suppl) J Nanomed Nanotechnol
ISSN: 2157-7439 JNMNT, an open access journal
Page 70
Notes:
Nano Congress 2016
August 01-02, 2016
conferenceseries.com
August 01-02, 2016 Manchester, UK
9th Nano Congress for Next Generation
Nanocomposites of layered clays and graphene/graphene oxide for drug delivery
Nada Mahmoud Hegazy
American University in Cairo, Egypt
Layered Double Hydroxides (LDHs) and graphene (G) and graphene oxide (GO) are combined to prepare a hybrid nanocomposite
to use in drug delivery. These composites combine the useful properties of both types of structures: high interacting surface
area, controlled release and biocompatibility, useful for good drug loading capacity and sustained drug release system. These
nanocomposites were tested for the loading and release of alendronate sodium, an osteoporotic drug with gastrointestinal adverse
effects and low bioavailabilty (<1%). The prepared hybrid nanocomposites incorporated 2% w/w of G or GO with a 3:1 M2+/M3+
ratio of Zn-Al LDH in its nitrate form. Alendronate sodium was loaded into the hybrid nanocomposites as well as the pristine LDH
by co-precipitation and ion exchange and all samples were characterized by powder x-ray diffraction, infrared spectroscopy and
zetasizer analysis. The amount of drug loaded and released was determined by UV/Vis spectroscopy. The co-precipitation samples
showed successful intercalation of the drug in a bi-layered arrangement within the LDH interlayer space. In spite of the intercalation
of the drug in the pristine LDH by ion exchange, hybrid nanocomposite samples with G or GO did not exhibit drug intercalation.
Drug loading for these samples seems to have been limited to surface adsorption on the LDH. Drug loading amounts ranged from
22.4% to 50.5% w/w, with noticeable increase in nanocomposites with G or GO prepared by co-precipitation. This increase is due
to the additional surface area provided by the G or GO for drug loading. A significant loading amount was observed for the pristine
LDH sample prepared by ion-exchange due to the longer contact time with the drug during preparation. The drug release was highly
sustained over 24 hours with minimum amounts released, and total release percentages at 24 hours ranging from 2.5% and 4.2%. This
sustained release behavior is due to the strongly attached drug anions, embedded in the interlayers of the positively charged brucite-
like layers. The observed variations in drug loading and release behavior is explained in terms of the charge on the brucite layers of
the LDH and the different interactions between the drug and the G and GO present.
Biography
Nada Mahmoud Hegazy has completed her Master’s degree in January 2016, from the American University in Cairo, in Nanotechnology, and in the process of
publishing the thesis work, and a Bachelor’s degree in May 2009 from the Faculty of Pharmacy, Cairo University. He has recieved a Diploma in Total Quality
Managment (TQM), in February 2011 from the American University in Cairo and a Clinical Diploma from Cairo University. He has been a former Research and
Development Specialist in a pharmaceutical company for one year, and currently a Quality Control Analyst in the National Organization for Drug Control and
Research.
Nada Mahmoud Hegazy, J Nanomed Nanotechnol 2016, 7:4 (Suppl)