nano-congress-2016_posters-accepted-abstracts

11 / 17

Volume 7, Issue 4(Suppl) J Nanomed Nanotechnol
ISSN: 2157-7439 JNMNT, an open access journal
Page 75
Nano Congress 2016
August 01-02, 2016
conferenceseries.com
August 01-02, 2016 Manchester, UK
9th Nano Congress for Next Generation
New-PEGylated PbS quantum dots for water-based applications
Francesca S Freyria, Jose Cordero, Justin Caram and Moungi Bawendi
Massachusetts Institute of Technology, USA
C olloidal nanochemistry has received tremendous interest over the past decade, especially the synthesis of nanoscale semiconductor
crystals capped with surfactant molecules and dispersed in solution (quantum dots (QDs)). Among them, near-infrared emitting
lead-based QDs have gained considerable attention since they exhibit attractive properties for the development of various emerging
applications, from optoelectronic-devices to photovoltaic cells and to fluorescence-based optical imaging. Most of these applications
require water as dispersion medium, whereas QDs synthesis is normally carried out in organic solvents, thus giving quantum dots
soluble in organic phases but insoluble in polar solvents. A ligand exchange process after the synthesis is the common route to obtain
water-soluble quantum dots. This two-steps method brings usually a decrease of the quantum yield, a possible emission shift and
an inhomogeneity in the particle size distribution, with many drawbacks for the final applications. This is more evident for the near
infrared and infrared emitting nanocrystals, whose optical quality even in organic phases is still not as high as for the visible emitting
QDs. We have developed a new kind of synthesis for water soluble PbS QDs, based on norbornene click-chemistry. This new synthesis
method eliminates the need of ligand exchange and confers a very high quantum yield and a high optical stability over months in
water. Finally, a hybrid system as model for solar energy devices has been physico-chemically and optically studied, by coupling a
supramolecular self-organization system with aqueous dispersions of PbS QDs.
Novel biocompatible nanoparticles: Generation and size-tuning by the formation of self-assembly templates
obtained from thermo-responsive monomer mixtures
Gerardo Byk
Bar Ilan University, Israel
We have developed new biocompatible, non-degradable, nano particles (NPs) well tolerated both in vitro and in vivo with
particularity peptide synthesis can be carried out on their surface. Although the NPs have a large range of well-defined sizes
ranging from 20 to 400 nm, they are all composed of the same monomers. Their shell composition, in contact with the biological
media, is uniformly composed of polyethylene-glycol, thus their biocompatibility remains high along different sizes. A proposed
peculiar mechanism of formation allowed maintaining their shell composition uniform. The conjugation of molecules to the NPs was
a real challenge since they are nano-hydrogels with high colloidal stability that can only be dialyzed for eventual removal of reagents.
Therefore, we have designed and proved a novel solid phase peptide synthesis method for Merrifield synthesis on nanoparticles based
on the embedment of the NPs in a permeable and removable magnetic matrix. Overall, the platform composed of the NPs and the
synthetic peptide is a useful tool for developing imaging methods for intracellular localization of the NPs using microscopy as we have
shown in vitro for PC-3 cells, and for in vivo tracking using the Zebra fish model.
J Nanomed Nanotechnol 2016, 7:4 (Suppl)