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Volume 7, Issue 4(Suppl) J Nanomed Nanotechnol
ISSN: 2157-7439 JNMNT, an open access journal
Page 68
Notes:
Nano Congress 2016
August 01-02, 2016
conferenceseries.com
August 01-02, 2016 Manchester, UK
9th Nano Congress for Next Generation
New approach to biomolecular self-assembly through formation of peptide architectures by artificial
supersaturation
Makoto Sakurai
National Institute for Materials Science, Japan
Biomolecular self-assembly is a bottom-up approach to form nano/microstructures through non-covalent interactions of
biomolecules. Construction of desired functional structures by self-assembled growth is of fundamental interest for applications
in fields such as biosensors, biodevices, tissue repair and for promising platforms in next-generation devices. Therefore, a deep
understanding of the growth mechanism is required. However, growth process from nanoscale aggregations to hierarchical
microstructures still remains unclear. Here, we report a new method of controlling and analyzing biomolecular self-assembly using
a methanolic solution of short dipeptide diphenylalanine (FF), which has been known as a core recognition motif of Alzheimer’s
b-amyloid polypeptide. The in situ observation of its growth gives unique information to understand growth mechanism of simple
microtubes and "diatom-like" porous microspheres, which are produced through the formation of a small nucleus in the artificial
local supersaturation. Although it is a simple model system, the method and interpretation will pave the way for controlled growth of
more complicated biological nano/microstructures.
Biography
Makoto Sakurai got his PhD from Keio University on the topic "Magnetism and Structure of Magnetic Superlattice". He studied mechanism of atom-manipulation
using scanning tunneling microscope (STM) and also developed a new technique of STM-induced light emission from atomic structures with the atom-resolved
spatial resolution, as a researcher at RIKEN and NIMS. He is studying new functionality caused by dynamic defects-manipulation in wide-band-gap oxide nano/
microstructures to achieve new-type computing architectures from 2007 and is also investigating for controlled self-assembly of peptide/molecules from 2013, as
a Senior Researcher at NIMS.
Makoto Sakurai, J Nanomed Nanotechnol 2016, 7:4 (Suppl)