infection-control-microbial-pathogenesis-2018-posters

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Journal of Infectious Diseases & Therapy |ISSN: 2332-0877 | Volume 6

June 25-26, 2018 | Vancouver, Canada

International Conference on

Infection, Disease Control and Prevention

Microbial Pathogenesis & Infectious Diseases

Synthesis, antimicrobial efficacy and structure-activity relationships of three series of benzalkonium salts

Marketa Benkova

University of Defence, Czech Republic

hree series of N-alkylammonium salts (7a-c, 8a-b, 9a-b) based on quaternary ammonium compounds with a different length

and type of carbon chain (C

, C

) were synthesized, characterized (EA, HRMS, NMR) and tested

in vitro

for antimicrobial

(antibacterial, antifungal and antialgal) activity. Furthermore, the critical micelle concentration (CMC), capacity factors k and

cytotoxicity were likewise measured to elucidate possible structure-activity relationships. The antimicrobial activity of the prepared

compounds has been evaluated and compared. All compounds being tested proved high efficacy against both Gram-positive and

Gram-negative bacterial strains, excluding the activity against multi-resistant

Pseudomonas aeruginosa

. Antifungal testing showed

high activity of most compounds against fungal strains (yeasts and filamentous fungi) except of

Aspergillus niger

. The relationship

between length of carbon chain and the efficiency has been observed. Series 7a-c proved high antialgal efficacy. Cell viability assay

confirmed an expected trend that increasing carbon chain length results in higher cytotoxicity.

J Infect Dis Ther 2018, Volume 6

DOI: 10.4172/2332-0877-C2-042