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Page 73
Journal of Infectious Diseases & Therapy |ISSN: 2332-0877 | Volume 6
June 25-26, 2018 | Vancouver, Canada
3
rd
International Conference on
2
nd
International Conference on
Infection, Disease Control and Prevention
Microbial Pathogenesis & Infectious Diseases
&
Synthesis, antimicrobial efficacy and structure-activity relationships of three series of benzalkonium salts
Marketa Benkova
University of Defence, Czech Republic
T
hree series of N-alkylammonium salts (7a-c, 8a-b, 9a-b) based on quaternary ammonium compounds with a different length
and type of carbon chain (C
12
, C
14
, C
16
) were synthesized, characterized (EA, HRMS, NMR) and tested
in vitro
for antimicrobial
(antibacterial, antifungal and antialgal) activity. Furthermore, the critical micelle concentration (CMC), capacity factors k and
cytotoxicity were likewise measured to elucidate possible structure-activity relationships. The antimicrobial activity of the prepared
compounds has been evaluated and compared. All compounds being tested proved high efficacy against both Gram-positive and
Gram-negative bacterial strains, excluding the activity against multi-resistant
Pseudomonas aeruginosa
. Antifungal testing showed
high activity of most compounds against fungal strains (yeasts and filamentous fungi) except of
Aspergillus niger
. The relationship
between length of carbon chain and the efficiency has been observed. Series 7a-c proved high antialgal efficacy. Cell viability assay
confirmed an expected trend that increasing carbon chain length results in higher cytotoxicity.
marketa.benkova11@gmail.comJ Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C2-042