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Journal of Infectious Diseases & Therapy |ISSN: 2332-0877 | Volume 6

June 25-26, 2018 | Vancouver, Canada

International Conference on

Infection, Disease Control and Prevention

Microbial Pathogenesis & Infectious Diseases

Evaluation of histopathological effects of contaminated unexpired gentamicin and pencillin g injections on

the kidney tissues of juvenile wistar rats

Iquo Takon

University of Calabar, Nigeria

he histo-pathological effects of contaminated gentamicin and penicillin G injections on the kidney tissues of juvenile wistar

rats have been investigated using standard microbiological and histo-pathological techniques. Freeze-dried and heat fixed thin

sections of wistar rats’ kidney were observed under the microscope using x10, x40 and x100 magnifications. The results revealed

marked necrosis and erosion of proximal borders especially the focal epithelium of proximal convoluted tubules(PCT) of the kidney,

with the retention of the cyto-architecture. Plasmolysis was observed in the epithelial cells of the distal convoluted tubules(DCT)

when treated with contaminated unexpired gentamicin injection sample as compared with control. Glomerular hypoplasia and

fibrosis of the Bowman’s space occurred in the kidney when compared with the control. Also medulla interstitial oedema leading to

focal tubular fibrosis as a result of microbial activity was observed when compared with control. Interstitial hemorrhage which led to

complete tubular necrosis with loss of defined tubular cyto- architecture was observed. This effect made the tissue fibrous, resulting

in a non-functional or shrunken kidney as compared to control. Results obtained from this work has raised serious health concerns,

considering the risk posed by contaminated drugs on patients.

J Infect Dis Ther 2018, Volume 6

DOI: 10.4172/2332-0877-C2-042