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Page 68
Journal of Infectious Diseases & Therapy |ISSN: 2332-0877 | Volume 6
June 25-26, 2018 | Vancouver, Canada
3
rd
International Conference on
2
nd
International Conference on
Infection, Disease Control and Prevention
Microbial Pathogenesis & Infectious Diseases
&
Evaluation of histopathological effects of contaminated unexpired gentamicin and pencillin g injections on
the kidney tissues of juvenile wistar rats
Iquo Takon
University of Calabar, Nigeria
T
he histo-pathological effects of contaminated gentamicin and penicillin G injections on the kidney tissues of juvenile wistar
rats have been investigated using standard microbiological and histo-pathological techniques. Freeze-dried and heat fixed thin
sections of wistar rats’ kidney were observed under the microscope using x10, x40 and x100 magnifications. The results revealed
marked necrosis and erosion of proximal borders especially the focal epithelium of proximal convoluted tubules(PCT) of the kidney,
with the retention of the cyto-architecture. Plasmolysis was observed in the epithelial cells of the distal convoluted tubules(DCT)
when treated with contaminated unexpired gentamicin injection sample as compared with control. Glomerular hypoplasia and
fibrosis of the Bowman’s space occurred in the kidney when compared with the control. Also medulla interstitial oedema leading to
focal tubular fibrosis as a result of microbial activity was observed when compared with control. Interstitial hemorrhage which led to
complete tubular necrosis with loss of defined tubular cyto- architecture was observed. This effect made the tissue fibrous, resulting
in a non-functional or shrunken kidney as compared to control. Results obtained from this work has raised serious health concerns,
considering the risk posed by contaminated drugs on patients.
iquotee@yahoo.comJ Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C2-042