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Volume 5, Issue 2 (Suppl)

J Infect Dis Ther 2017

ISSN: 2332-0877, JIDT an open access journal

Infection Congress 2017

May 11-12, 2017

May 11-12, 2017 Barcelona, Spain

International Congress on

Infectious Diseases

J Infect Dis Ther 2017, 5:2 (Suppl)

A critical appraisal of tubercular lesions of the breast: A pathologist’s perspective of diagnostic challenges

Zeeba S Jairajpuri, Safia Rana, Shaan Khetrapal

and

Sujata Jetley

Hamdard Institute of Medical Science & Research, India

Statement of the Problem:

India is a developing country where tuberculosis (TB) is endemic with both pulmonary and extra

pulmonary manifestations of the disease. Tuberculosis has been recognized as an affliction with an enormous impact in terms

of morbidity, mortality and economic cost. TB affects primarily the lungs, however extra-pulmonary TB involving lymph nodes,

intestine and spine are also common. TB of breast is remains extremely rare even in developing countries where pulmonary and other

forms of extra pulmonary manifestations of TB are endemic. Breast tuberculosis is a rare presentation and its importance lies in the

fact that it may mimic malignancy or present as inflammatory lump/abscess.

Aim:

The purpose of the present study is to highlight the importance of breast TB, and its diagnostic challenges.

Methodology & Theoretical Orientation:

It was a retrospective study conducted at Hamdard Institute of Medical Sciences and

Research & associated Hakim Abdul Hamid Centenary Hospital, New Delhi, over a period of two years between 2013 and 2015

during which eight cases of breast lesions were diagnosed as tuberculosis.

Findings:

Granulomas were seen in five cases while three cases revealed only few epithelioid cells. Necrosis was seen in all cases.

Histopathological evaluation was available in six cases, while acid fast bacilli (AFB) were positive in three; the characteristic

granulomas were seen in all the six cases.

Conclusion & Significance:

Its importance lies in the fact that due to its infrequent occurrence and the chances of a mistaken

identity with other disease, it entails a high index of suspicion. The disease is clinically known to simulate many diseases of breast like

carcinoma, abscess, chronic granulomatous inflammation, and chronic non-specific inflammation and duct ectasia. In developing

countries like India, clinical history and cyto-morphological features of epithelioid cell granulomas with or without necrosis and AFB

negative on FNAC smears, a therapeutic trial of antitubercular drugs may be instituted.