infection-congress-2017-posters-accepted-abstracts

Page 68

conferenceseries

.com

Volume 5, Issue 2 (Suppl)

J Infect Dis Ther 2017

ISSN: 2332-0877, JIDT an open access journal

Infection Congress 2017

May 11-12, 2017

May 11-12, 2017 Barcelona, Spain

International Congress on

Infectious Diseases

J Infect Dis Ther 2017, 5:2 (Suppl)

Distinguishing chikungunya infection fromdengue infection among children admitted at a tertiary hospital

from 2012-2013 using clinical and laboratory predictors: A retrospective cross-sectional study

Andrew Phillip P Ong, Robert Dennis Garcia

and

Shirley Josefina

Makati Medical Center, Philippines

Background:

Dengue fever and chikungunya fever are both mosquito-borne illness which have emerged as major infectious diseases

especially in the tropical and subtropical regions of the world. Due to similarities in the symptomatology of both chikungunya and

dengue fever infections, it is necessary to differentiate the two illnesses clinically and/or by laboratory testing.

Objectives:

Aim of this study is to compare the clinical manifestations and laboratory features which would differentiate chikungunya

and dengue infections during the acute viremic phase of the illness.

Design:

This is a retrospective cross-sectional study of children 18 years and younger diagnosed with chikungunya fever by serum

PCR and dengue fever by serum dengue IgM or NS1 seen from January 1, 2012 to January 31, 2013.

Setting:

Study was conducted at Makati Medical Center, Makati City, Philippines.

Main Outcome Measure:

Selected data on clinical symptomatology, physical examination findings and laboratory examinations

were obtained from review of medical charts, laboratory records and physician’s records.

Results:

Eighteen patients with chikungunya fever and 54 with dengue fever were analyzed for clinical symptomatology; dengue

patients were significantly more likely to have mucosal bleeding, fever, abdominal pain and longer illness duration, while chikungunya

patients were significantly more likely to exhibit malaise, arthralgia and arthritis. Among the laboratory tests, dengue patients were

significantly more likely to have thrombocytopenia (platelets below 100,000), while chikungunya patients were more likely to have

an elevated CRP.

Conclusion:

Chikungunya patients can be differentiated from dengue patients at presentation to the hospital despite substantial

overlap in the clinical symptomatology, physical examination findings and laboratory examinations.