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.com
Volume 5, Issue 3 (Suppl)
Mod Chem Appl, an open access journal
ISSN: 2329-6798
Global Chemistry 2017
September 04-06, 2017
September 04-06, 2017 | London, UK
5
th
Global Chemistry Congress
Nano-TiCl
2
/cellulose as an eco-friendly and bio-based catalyst for one-pot synthesis of ethyl-2-amino-
4-aryl-4H-chromene-3-carboxylate derivatives
Elaheh Akbarzadeh, Bahareh Sadeghi
and
Elham Arabian
Islamic Azad University, Yazd Branch, Iran
R
ecently heterogeneous catalysts have attracted paramount importance in many aspects including chemical and energy
industries. It is noteworthy to mention that these catalysts are valuable due to their simple handling and storage, easy
separation and regenerability. Among these heterogeneous catalysts, polysaccharides especially cellulose has beenwidely studied
as it is the most abundant natural carbon-based biopolymers in the world. It has different fascinating properties including
mechanical robustness, biodegradability, hydrophilicity and biocompatibility. Therefore, cellulose has found a wide application
in a variety of areas such as pharmacy, agriculture, medical science, industries and so many other related branches.3-5 Also,
cellulose susceptible to bond with Lewis acids because of its free OH groups. Hence, with important properties of cellulose
in hand and some appealing features of nano-scale materials, chemists can approach to their goal. In recent years, we have
been trying to conduct synthetic methodologies under environmentally friendly conditions. In this regard, we have reported
convenient procedutres using various efficient nano catalysts.6-8 Based on these achievements and in continuation of our
previous experiences, we would like to report nano-TiCl4/cellulose as a bio-based and eco-friendly Lewis acid catalyst for
synthesis of ethyl-2-amino-4-aryl-4H-chromene-3-carboxylate derivatives. The catalyst was prepared via reaction of nano-
cellulose and TiCl4 in dichloromethane as solvent under room temperature conditions. This catalyst has been characterized
by fourier transform infrared spectroscopy, field emission scanning electron microscopy, powder X-ray diffraction, energy
dispersive X-ray spectroscopy, X-ray fluorescence techniques, and transmission electron microscopy. Nano-TiCl2/cellulose
has been shown to effectively promote multi-component synthesis of ethyl-2-amino-4-aryl-4H-chromene-3-carboxylate
derivatives by reaction of aldehydes, resorsinol, and ethylcyanoacetate under ethanol reflux. All prepared compounds were
characterized with melting points, 1H NMR and 13C NMR. Simple methodology, an eco-friendly catalyst, a clean procedure,
easy work-up, and excellent yields are some of the important advantages of this protocol.
akbarzadeh.elaheh@yahoo.comMod Chem Appl 2017, 5:3(Suppl)
DOI: 10.4172/2329-6798-C1-006