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Volume 5, Issue 3 (Suppl)

Mod Chem Appl, an open access journal

ISSN: 2329-6798

Global Chemistry 2017

September 04-06, 2017

September 04-06, 2017 | London, UK

Global Chemistry Congress

Effect of cimetidine on the pharmacokinetics of paracetamol in human subjects

Mahmoud Amina Bello

A,B.U Zaria-Nigeria

Statement of the Problem:

the recognition of a drug interaction is usually the result of either enhanced or diminished

therapeutic effect. This may be from the concomitant administration of another agent, an alteration in physiology or from the

effect of diseases.Purpose of the study is to study the effect of

Cimetidine

on the pharmacokinetics of

paracetamol

in human

subjects..

Methodology & Theoretical Orientation:

The study was divided into two phases. The non-invasive method of estimating

drug levels in plasma was used.

Findings:

The results of this study have shown that

cimetidine

affected the pharmacokinetics of

paracetamol

in delayed

treatments than in concurrent treatment.

Conclusion & Significance:

Cimetidine

has affected the pharmacokinetics of

Paracetamol

which was obvious when it was

administered an hour before Paracetamol tablets.The rationale of single dose study here is to observe the profile of the

interaction without any disturbance by the multiple regimen. Recommendations are made to administer cimetidine and

paracetamol concurrently.

Mod Chem Appl 2017, 5:3(Suppl)

DOI: 10.4172/2329-6798-C1-006