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.com
Volume 5, Issue 3 (Suppl)
Mod Chem Appl, an open access journal
ISSN: 2329-6798
Global Chemistry 2017
September 04-06, 2017
September 04-06, 2017 | London, UK
5
th
Global Chemistry Congress
Novel and versatile solid-state chemiluminescence sensor based on TiO2-Ru(bpy)32+ nanoparticles
for pharmaceutical drugs detection
Mohamed O Amin, Entesar Al-Hetlani
and
Metwally Madkour
Kuwait University, Kuwait
T
his work describes a novel and versatile solid-state sensor for analytes detection using Ru(bpy)
3
2+
-Ce(IV). Herein, we report
the synthesis, characterisation, optimisation and application of a new type of hybrid nanoparticles (NPs). Mesoporous
TiO
2
-Ru(bpy)
3
2+
NPs were prepared using a modified sol-gel method by incorporating Ru(bpy)
3
2+
into the initial reaction
mixture at various concentrations. The resultant bright orange precipitate was characterised via: TEM, N
2
sorpometry, ICP-
OES, Raman and UV-Vis spectroscopy techniques. The concentration of Ru(bpy)
3
2+
complex in the NPs was quantified and its
chemiluminescence (CL) response was compared to the same concentration in the liquid phase using oxalate as model analyte.
The results showed that this type of hybrid material exhibited higher CL signal compared to the liquid phase due to enlarged
surface area of the hybrid NPs (~149.6 m²/g). The amount of TiO
2
-Ru(bpy)
3
2+
. NPs and the effect of the oxidant flow rate were
also investigated to optimize the CL signal. The optimized system was further used to detect oxalate and two pharmaceutical
drugs; imipramine and promazine. The linearity of both drugs was in the range of 1-100 pM with limits of detection (LoD) of
0.1 and 0.5 pM, respectively. This approach is considered simple, low cost, facile and can be applied to a wide range of analytes.
Biography
Mohamed O Amin completed his Graduation at Kuwait University and currently pursuing MSc in Medicinal Chemistry.
mohamed.o.amin@hotmail.comMohamed O Amin et al., Mod Chem Appl 2017, 5:3(Suppl)
DOI: 10.4172/2329-6798-C1-006