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conferenceseries
.com
Euro Pathology 2018 | Hematologic Oncology 2018
June 20-21, 2018
Volume 8
Journal of Clinical & Experimental Pathology
ISSN : 2161-0681
15
th
EUROPEAN PATHOLOGY CONGRESS
&
LEUKEMIA AND HEMATOLOGIC ONCOLOGY
June 20-21, 2018 | Paris, France
14
th
International Conference on
JOINT EVENT
GATA3 expression in primary cutaneous mucinous carcinoma
Akanksha Gupta
1
, Michael Murphy
2
, Richard Cartun
1
and Zendee Elaba
3
1
Hartford Hospital, USA
2
University of Connecticut, USA
3
University of Massachusetts, USA
Introduction:
Primary cutaneous mucinous carcinoma (PCMC) is a rare adnexal tumor of sweat gland origin with an indolent
course. The primary challenge in diagnosis is distinguishing PCMC from metastatic mucinous breast carcinoma (MMBC)-an
important distinction because of the poorer prognosis with metastatic disease, requiring aggressive management. GATA3 binding
protein is a transcription factor known to be a sensitive marker for breast and urothelial carcinomas. Most primary and metastatic
breast carcinomas express GATA3, making it useful in evaluating metastatic disease. GATA3 expression has also been demonstrated
in various epithelial skin tumors but it has not been specifically studied in a cohort of PCMC.
Case Series:
We evaluated the potential of GATA3 as a distinguishing marker between PCMC and MMBC by applying it in
four consecutive cases of PCMC diagnosed at our institution. All patients were females, making mammary metastasis a relevant
diagnostic consideration. All cases were CK7 (+)/CK20 (-), CDX2 (-) and expressed mammaglobin, ER and PR. Based on
morphology and immunophenotype alone, the cases were practically indistinguishable from MMBC, except that they showed
p63 (+) myoepithelial cells, suggestive of a primary cutaneous process. For each case, the diagnosis of PCMC was eventually made
after possible extracutaneous primaries had been excluded by extensive systemic workup.
Result:
All PCMC cases showed strong nuclear GATA3 expression.
Conclusion:
GATA3 immunohistochemistry is not useful in contrasting PCMC from MMBC. In differentiating these histologic
mimics, additional markers and thorough systemic workup are necessary to establish primary cutaneous derivation.
Biography
Akanksha Gupta has completed her MBBS, and currently is a MD third year Pathology Resident at Hartford Hospital, CT, USA. She did a Pathology Residency in
India and passed it with a Gold Medal and moved to US in 2013. While doing her second year Nephropathology fellowship in University of North Carolina at Chapel
Hill, NC, USA, she has published five abstract/paper publications, 12 poster presentations, seven oral presentations and one online publication. She is very adept
at oral presentations.
Akanksha.Gupta@hhchealth.orgAkanksha Gupta et al., J Clin Exp Pathol 2018, Volume 8
DOI: 10.4172/2161-0681-C1-045