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Euro Pathology 2018 | Hematologic Oncology 2018
June 20-21, 2018
Volume 8 Journal of Clinical & Experimental Pathology
ISSN : 2161-0681
15 th EUROPEAN PATHOLOGY CONGRESS
&
LEUKEMIA AND HEMATOLOGIC ONCOLOGY
June 20-21, 2018 | Paris, France
14th International Conference on
JOINT EVENT
Hemostatic profile in patients of myeloproliferative neoplasms- A 5 year experience from a tertiary care centre
in North India
Rashmi Kushwaha, Yatendra, Geeta Yadav, Mili Jain, S P Verma, U S Singh, A Kumar and Tripathi A K
King George’s Medical University, India
Background: Patients of myeloproliferative neoplasm (MPN) commonly present with abnormalities in coagulation tests that are
consistent with hypercoagulable state. Some individuals with MPN exhibit a pattern of exclusive bleeding or thrombotic events;
many others have both bleeding and thrombosis.
Objectives: To assess the hemostatic defects and platelet functions in patients of MPN.
Methods: Five year prospective study done at a tertiary care center in North India. All recently diagnosed cases of MPN along
with 50 age and sex matched controls were included. Patients on antiplatelet drugs, anti myeloproliferative treatment, vitamin K
agonists or antagonists, OCP’s, Platelet count <1, 00, 000/µl, high grade fever, liver disease, pregnancy were excluded. All the
patients underwent screening investigations like CBC, peripheral smear evaluation, bleeding time, prothrombin time, activated
partial thromboplastin time, Protein C and S measurement, aggregation with ADP 5µM (CHRONOLOG 700).
Result: Fifty cases were included. There was an occult prothrombotic state, suggested by significantly (p<0.001) reduced levels of
Protein C, Protein S. But no patient presented with frank thrombosis. Eight out of 50 patients had hemorrhagic manifestations ranging
from subdural hematoma to pin point petechial hemorrhages. Patients of CML-CP, ET, PV, PMF, MPN-NOS showed significantly
reduced maximal aggregation with 5 µMADP (p<0.001). MPV also showed a statistically significant increase in these patients.
Conclusion: Thrombohemorrhagic complications significantly affect the morbidity and mortality of MPN patients. Timely diagnosis
of hemostatic abnormalities can decrease the morbidity in these patients.
Biography
Rashmi Kushwaha has completed her MD Pathology from Rajiv Gandhi University of Health Sciences, Karnataka, India. At present, she is working as Additional
Professor, Lymphoma-Leukemia Lab, Department of Pathology, King George’s Medical University, Lucknow, India. She has been working in the above mentioned
lab since 10 years. She has 28 scientific paper publications in indexed journals and two research projects. She has delivered nine guest lectures in various
conferences. She is trained in flow cytometric immunophenotyping, platelet aggregation studies and coagulation workup.
Rashmi Kushwaha et al., J Clin Exp Pathol 2018, Volume 8
DOI: 10.4172/2161-0681-C1-045