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conferenceseries.com
Euro Pathology 2018 | Hematologic Oncology 2018
June 20-21, 2018
Volume 8 Journal of Clinical & Experimental Pathology
ISSN : 2161-0681
15 th EUROPEAN PATHOLOGY CONGRESS
&
LEUKEMIA AND HEMATOLOGIC ONCOLOGY
June 20-21, 2018 | Paris, France
14th International Conference on
JOINT EVENT
Mean platelet volume and mean platelet volume/platelet count ratio as markers for hepatocellular
carcinoma in patients with chronic hepatitis C virus related cirrhosis
Gamal Y Abo-Raia, Khaled Metwaly, Eman Abdel Sameea, Gasser El-Azab, Medhat Assem, Mohamed Abbas and Talaat Zakareya
Menoufia University, Egypt
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. The lack of efficient and precise HCC
biomarkers prevents early detection resulting in a poor prognosis. Recently, mean platelet volume (MPV) and MPV/platelet
count (PC) ratio have been proposed as potential markers of HCC. This study was carried out to verify MPV and MPV/PC ratio
in diagnosis of HCC in Egyptian patients with chronic hepatitis C related liver cirrhosis. One hundred and fifty chronic hepatitis C
(CHC) patients with chronic hepatitis, cirrhosis or HCC were enrolled in the study. The levels of alpha-feto protein (AFP), MPV and
MPV/PC ratio were determined compared to 50 healthy persons. MPV and MPV/CP ratios were higher in patients with cirrhosis and
those with HCC. The cut off level for MPV for detection of HCC was 10.1 fl, with sensitivity of 70% and specificity of 57%. At a cut
off level of 0.82, the sensitivity of MPV/CP ratio was 79.6% and specificity was 72.7%. AFP showed sensitivity 80% and specificity
82% at cut-off level of 16.9 ng/dl. MPV and MPV/PC ratios are less sensitive and specific than AFP as markers for HCC and they
may be used only in association with other markers to improve sensitivity of tumor detection.
Biography
Gamal Y Abo-Raia is an Assistant Professor of Clinical Pathology, Dept. of Clinical & Chemical Pathology, at National Liver Institute, Menoufia University. He is
Director of Clinical Chemistry Unit at National Liver Institute lab. He has published more than 20 papers in reputed journals. He is a supervisor of more than 20
Master’s & Doctorate theses.
Gamal Y Abo-Raia et al., J Clin Exp Pathol 2018, Volume 8
DOI: 10.4172/2161-0681-C1-045