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conferenceseries.com
Euro Pathology 2018 | Hematologic Oncology 2018
June 20-21, 2018
Volume 8 Journal of Clinical & Experimental Pathology
ISSN : 2161-0681
15 th EUROPEAN PATHOLOGY CONGRESS
&
LEUKEMIA AND HEMATOLOGIC ONCOLOGY
June 20-21, 2018 | Paris, France
14th International Conference on
JOINT EVENT
Clinicopathological evaluation of abnormal uterine bleeding (AUB) and its correlation with biochemical
hormone profile in perimenopausal women
Malti Kumari Maurya
King George’s Medical University (KGMU), India
Introduction: Perimenopausal women faces menstrual problems inform of cycle irregularity in form of variation in both length and
heaviness of bleeding episodes. Follicular development during this phase is erratic, leading to estrogen level variability. Thus, detailed
characterization of sex hormones dynamics during the perimenopause is important for understanding its potential implications for
reproductive cancers and other health outcomes.
Objective: To evaluate the clinical features and histopathological findings in abnormal uterine bleeding and correlate with hormone
profile in perimenopausal women.
Materials & Methods: A total of 156 endometrial curettage samples of perimenopausal women age group (40-50 years) which
were undergone D&C for AUB were collected and processed and classified according WHO criteria. 2-3 ml serum was collected
between day two to day fourth of period and LH, FSH, Estradiol and progesterone hormone analysis was done by chemiluminescent
microparticle immunoassay.
Results: The predominant pattern of endometrium among benign category was proliferative 46 (30.6%) and disordered proliferative
phase endometrium 40 (26.6%) followed by secretory 12 (8%) and mixed endometrium 11 (7.3%). In premalignant group,
33 (22%) had hyperplasia without atypia and 2 (1.3%) had atypical hyperplasia. Patients with benign endometrial lesions (102)
and hyperplasia (33) presented with heavy menstrual bleed 91% and 94% respectively while all three patients of malignant lesions
complaint intermenstrual bleeding (100%). (p=0.001). No statistically significant correlation was found between hormone levels and
endometrial histological pattern.
Conclusion: In perimenopausal women, intermenstrual bleeding may represent an alarming symptom of endometrial malignancy.
Histopathological pattern of endometrium and clinicopathological factors can predict further management and outcome.
Biography
Malti Kumari Maurya has completed her MD Pathology from King George’s Medical University (KGMU), Lucknow, India in 2008. Then joined as a Lecturer in 2009
in the same Department and promoted to Associate Professor in 2015. She is actively participating in both teaching undergraduate and postgraduate students
along with research work and attended national international CME. Her field of interest is gynecologic pathology, onco path, oral and gall bladder tumor. She has
published more than 20 papers in reputed journals and serving as reviewer in two to four journals.
Malti Kumari Maurya, J Clin Exp Pathol 2018, Volume 8
DOI: 10.4172/2161-0681-C1-045