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conferenceseries.com
Volume 8, Issue 2 (Suppl) Chem Sci J 2017
ISSN: 2150-3494 CSJ, an open access journal Euro Chemistry 2017
May 11-13, 2017
May 11-13, 2017 Barcelona, Spain
4th European Chemistry Congress
Chem Sci J 2017, 8:2(Suppl)
Application response surface methodology for determination optimization of trace zinc in environmental
samples by adsorptive stripping voltammetry
Deswati, Hamzar Suyani, Rahmiana Zein and Admin Alif
Andalas University, Indonesia
Adsorptive stripping voltammetry is one of the stripping voltammetry method that is widely used in the analysis of heavy metals
because it has good sensitivity. metals with very small concentrations can be analyzed. The purpose of this study was to obtain
the optimum condition of the Zn metal ions simultaneously. To achieve these objectives. required an optimization technique of
analytical procedures by using Response Surface Methodology.with Central Composite Design (CCD). The research design was used
in this study is a CCD with 4 variables. 3 level and 31 a combination of treatments. The first step of 2k factorial design optimization
are: to give the highest level of code values (+1). the lowest level (-1) and code (0) as the center point. Programs that will be used for
statistical data processing. namely Mini Tab using RSM. Based on data analysis with response surface method. the obtained optimum
conditions for the determination of zinc is: calcon concentration of 0.71 mmol/L; pH = 7.18; accumulation potential -0.56 V and
the accumulation time 62.16 s. From the results obtained optimum conditions RSD of 2.5% with a recovery of 98.01%. respectively.
Limit of Detection (LOD) for Zn(II) was 1.21 (µg /L). RSM has been successfully applied to the determination of Zn in environmental
samples fast and effectively.
Synthesis of methane-linked bis-heterocycles containing the 1,5-disubstituted-tetrazole moiety via Ugi-
azide based methodologies
Alejandro Islas-Jácome and Rocio Gámez-Montaño
UNAM, CDMX, Mexico
Bis-heterocycles are structurally complex compounds having two linked, fused, merged or bound heterocyclic frameworks,1 which
have attracted much attention of synthetic community due to their potential applications in agrochemistry, optics, material
science, and medicinal chemistry.2 Moreover, 1,5-disubstituted-tetrazoles (1,5-DS-T’s) are known as resistant bioisosters of the cis-
amide bond of peptides,3 which are present in numerous valuable drugs like the 3rd generation cephalosporin antibiotic Latamoxeb.4
Besides, 1,5-DS-T’s are suitable precursors of a plethora of MOF´s and chelating agents.5 Thus, according to our ongoing program
to develop short and versatile Ugi-azide based methodologies toward a variety of methane-linked bis-heterocycles containing the
1,5-DS-T moiety, we herein show our most recent published results. In 2013, we described the synthesis of azepino[4,5-b]indol-
4-one-1,5-1H-tetrazoles in two steps: i) one pot (Ugi-azide/N-acylation/SN2), and ii) free radical mediated cyclization, as well as
in silico studies as 5-Ht6R ligands using docking techniques (Figure 1a).6 In 2014, we reported the synthesis of 2,3,4,9-tetrahydro-
-carboline-1,5-1H-tetrazoles by a one pot Ugi-azide / Pictet-Spengler process (Figure 1b).7 In 2014, we reported the synthesis of
chromen-4-ones-1,5-1H-tetrazoles via the Ugi-azide reaction and in vitro studies of antiparasitic properties against E. histolytica,
G. lamblia, and T. vaginalis.8 Then, in 2015 we extended this work synthesizing some fluorinated analogs, which together with the
previously synthesized bis-heterocycles were assayed in vitro against P. aeruginosa, S. aureus, S. schenckii, C. albicans, and C. tropicalis
(Figure 1c).9 Finally, just recently in 2016, we reported the synthesis of novel 3-tetrazolyl-tetrazolo[1,5-a]quinolines via a novel one
pot Ugi-azide / SNAr / ring-chain azido-tautomerization process (Figure 1d).10 As seen, the Ugi-azide reaction or its combination
with further cyclization processes allows the rapid synthesis of a variety of methane-linked bis-heterocycles with potential application
mainly in medicinal chemistry because 1,5-DS-T framework has been suitably combined with other heterocyclic systems, which are
present in numerous bioactive products, even in drugs.