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Volume 8, Issue 2 (Suppl) Chem Sci J 2017
ISSN: 2150-3494 CSJ, an open access journal Euro Chemistry 2017
May 11-13, 2017
May 11-13, 2017 Barcelona, Spain
4th European Chemistry Congress
Krishnendu Pal, Chem Sci J 2017, 8:2(Suppl)
Biophysical characterization of dynamic hysteresis and energetics of the gating processes of the voltage
gated sodium ion channel using nonequilibrium response spectroscopy
Krishnendu Pal
S N Bose National Centre for Basic Sciences, India
Here we have studied the dynamic as well as the non-equilibrium thermodynamic response properties of voltage-gated Na-ion
channel. Using sinusoidally oscillating external voltage protocol as Nonequilbrium Response Spectroscopic tool, we have both
kinetically and energetically studied the non-equilibrium steady state properties of dynamic hysteresis in det ails. We have estimated
the work done associated with the dynamic memory due to a cycle of oscillating voltage. We have quantitatively characterised the
loop area of ionic current which gives information about the work done to sustain the dynamic memory only for ion conduction,
while the loop area of total entropy production rate gives the estimate of work done for overall gating dynamics. The maximum
dynamic memory of Na-channel not only depends on the frequency and amplitude but it also depends sensitively on the mean
of the oscillating voltage and here we have shown how the system optimize the dynamic memory itself in the biophysical range of
field parameters. The relation between the average ionic current with increasing frequency corresponds to the nature of the average
dissipative work done at steady state. It is also important to understand that the utilization of the energy from the external field can
not be directly obtained only from the measurement of ionic current but also requires nonequilibrium thermodynamic study.
Biography
Krishnendu Pal, 27 years, is doing PhD in S.N. Bose National Centre For Basic Sciences, Kolkata-106, India. His area of research includes theoretical and
computational investigation of kinetics and nonequilibrium thermodynamics of Dynamic hysteresis, Drug bindings(Local Anesthetics), Inactivation process of
voltage gated sodium ion channel and study of stochastic resonance in neurons.