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Volume 6, Issue 4 (Suppl) Clin Pharmacol Biopharm, an open access journal
ISSN: 2167-065X
Page 52
Euro Biopharma & Ethnopharmacology 2017
November 09-11, 2017
&
6th International Conference and Exhibition on
November 09-11, 2017 Vienna, Austria
4th EUROPEAN BIOPHARMA CONGRESS
PHARMACOLOGY AND ETHNOPHARMACOLOGY
Joint Event
Antitumor prperties of curcumin loaded polymeric electrospun mats
Spiro M Konstantinov1, Antonios G X Trochopoulos1, Maya M Zaharieva3, Theodora N Athanassova1, Yana Ilieva1, GyuldzhanH Yakub2, MilenaG Ignatova2,
IliyaB Rashkov2, NevenaE Manolova2, D Momekova 1 and HristoM Najdenski3
1Medical University of Sofia, Faculty of Pharmacy
2Institute of Polymers, Bulgarian Academy of Sciences
3Institute of Microbiology, Bulgarian Academy of Sciences
Malignancies are the second cause for death in humans worldwide. Despite many newly introduced and approved targeted
drugs the problem of multidrug resistance and serious side effects remains unsolved and opens the search for effective natural
products with fewer side effects. Curcumin is a practically non-toxic compound of plant origin with own antineoplastic and NF-kB
inhibitory activities. Curcumin is one of the most popular drugs derived from Ayurveda investigated the cytotoxic
activity of curcumin loaded electrospun mats in human hepatic and colon carcinoma cell lines (HEP-G2 and HT-29). Disks with
5 mm diameter of the electrospun mats caused nearly 80% inhibition in HT-29 colorectal cells. The efficacy against the HEP-G2
hepatocellular carcinoma cells was weaker. The matsshowed antibacterial features and were found to be biocompatible with human
tissues of different origin. The tested polymeric mats increased the accumulation of curcumin inside of the malignant cells as
estimated by fluorescent microscopy. One of the polymeric mats represents fully water soluble form of curcumin that may have
distinct pharmacokinetic advantages.Taken together our experimental findings indicate that the non-toxic yellow pigment curcumin
after inclusion into electrospun polymeric mats can be used for topical treatment of liver lesions (e.g. colorectal cancer metastases)
and these results are promising in terms of further clinical application.
Acknowledgements: The study was partially supported by the Grant DFNI – T02/1 from the Bulgarian National Science Fund.
Spiro M Konstantinov et al., Clin Pharmacol Biopharm 2017, 6:4(Suppl)
DOI: 10.4172/2167-065X-C1-025