19 / 28
Notes:
Volume 6, Issue 4 (Suppl)
Clin Pharmacol Biopharm, an open access journal
ISSN: 2167-065X
Page 43
Euro Biopharma & Ethnopharmacology 2017
November 09-11, 2017
&
6
th
International Conference and Exhibition on
November 09-11, 2017 Vienna, Austria
4
th
EUROPEAN BIOPHARMA CONGRESS
PHARMACOLOGY AND ETHNOPHARMACOLOGY
Joint Event
Antineoplastic activity of cannabidiol containing products
Spiro M Konstantinov, Antonios G X Trochopoulos
1
, Maya M Zaharieva
3
, Theodora N Athanassova
1
, Yana Ilieva
1
, Gyuldzhan H Yakub
2
, Milena G Ignatova
2
,
Iliya B Rashkov
2
, Nevena E Manolova
2
, D Momekova
1
and
Hristo M Najdenski
3
1
Medical University of Sofia, Bulgaria
2
Institute of Polymers - Bulgarian Academy of Sciences, Bulgaria
3
Institute of Microbiology - Bulgarian Academy of Sciences, Bulgaria
M
alignancies are the second cause of death in humans worldwide. Despite many newly introduced and approved targeted drugs,
the problem of multidrug resistance and serious side effects remain unsolved and open the search for effective natural products
with fewer side effects. Curcumin is a practically non-toxic compound of plant origin with own antineoplastic and NF-kB inhibitory
activities. Curcumin is one of the most popular drugs derived from Ayurveda traditions. We investigated the cytotoxic activity of
curcumin loaded electrospun mats in human hepatic and colon carcinoma cell lines (HEP-G2 and HT-29). Disks with 5 mm diameter
of the electrospun mats caused nearly 80% inhibition in HT-29 colorectal cells. The efficacy against the HEP-G2 hepatocellular
carcinoma cells was weaker.Themats showed antibacterial features and were found to be biocompatible with human tissues of different
origin. The tested polymeric mats increased the accumulation of curcumin inside of the malignant cells as estimated by fluorescent
microscopy. One of the polymeric mats represents fully water soluble form of curcumin that may have distinct pharmacokinetic
advantages. Taken together our experimental findings indicate that the non-toxic yellow pigment curcumin after inclusion into
electrospun polymeric mats can be used for topical treatment of liver lesions (e.g. colorectal cancer metastases) and these results are
promising in terms of further clinical application.
konstantinov.spiromihaylov@gmail.comSpiro Konstantinov et al., Clin Pharmacol Biopharm 2017, 6:4(Suppl)
DOI: 10.4172/2167-065X-C1-025