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Notes:
Volume 6, Issue 4 (Suppl)
Clin Pharmacol Biopharm, an open access journal
ISSN: 2167-065X
Page 59
Euro Biopharma & Ethnopharmacology 2017
November 09-11, 2017
&
6
th
International Conference and Exhibition on
November 09-11, 2017 Vienna, Austria
4
th
EUROPEAN BIOPHARMA CONGRESS
PHARMACOLOGY AND ETHNOPHARMACOLOGY
Joint Event
Treatment of deep vein thrombosis via regulating balance of Th1/Th2 subsets with chinese medicine
compound
Bin Wang, Ming Liu, Qingzhi Hao, Dawei Zhang
and
Fuchen Song
Shandong University of Traditional Chinese Medicine, China
Objective:
To discuss the changing rule of Th1/Th2 subsets in deep vein thrombosis (DVT) and the mechanism of Chinese
medicine compound Xiao Shuan Tong Mai Granules (XSTMG) in regulating the balance of Th1/Th2 subsets.
Methods:
Sixty patients with acute DVT were divided into 2 groups; XSTMG and western medicine group (ITCWMG) and
western medicine group (WMG), thirty healthy persons were selected to be in normal group. Flow cytometry and ELISA were
performed to observe the frequency change of Th1 andTh2 cells in peripheral blood and the level of TNF-α, IFN-γ, IL-4, IL-10
in plasma.
Results:
After using Xiao Shuan TongMai Granules, the TNF-α and IFN-γ levels inWMGwere higher than those in ITCWMG;
the levels of IL-4 and IL-10 in ITCWMG were higher than those in WMG (P<0.05); the improvement of circumference was
better in ITCWMG than that in WMG after treatment.
Conclusion:
Xiao Shuan Tong Mai Granules can inhibit TNF-α and IFN-γ transcription, enhance IL-4 and IL-10 expression,
and increase the proportion of Th2 subsets. It also can predominantly induce T cells response bias to Th2 subsets, reduce the
inflammatory reaction, protect vascular endothelial cells. Thrombus recanalization can be accelerated and the limb swelling
will be reduced.
Biography
Bin Wang completed his PhD degree from Shandong University of Traditional Chinese Medicine in 2008. He is now working in the Peripheral Vascular Surgery
Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine. He had published more than 10 papers in reputed journals in the recent
five years.
2801505631@qq.comBin Wang et al., Clin Pharmacol Biopharm 2017, 6:4(Suppl)
DOI: 10.4172/2167-065X-C1-026