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43

conferenceseries LLC Ltd

3

rd

International Conference on

3

rd

International Conference on

Ecology, Ecosystem and Conservation Biology

Microbial Ecology & Eco Systems

&

March 18-19, 2019 | Chicago, USA

Find More Information @

https://conferenceseries.com/america/

MARCH 2019 Conference Series LLC Ltd

Serodiagnosis of

human herpesvirus 8

in women with breast

cancer

Dania Mudar Shakir

University of Basra, Iraq

H

uman herpesvirus 8 (HHV-8)

is a common virus in the

Mediterranean region. It has

been linked to a number of

malignancies, and it is believed

to be the causative agent

in certain cases. The aim of

this study was to evaluate

the distribution and possible

association between HHV-8

and breast carcinoma, and

to assess the risk factors

associated with an HHV-8

infection. A total of 90 blood

samples were collected. Forty-

five of these patients were

recently diagnosed with breast

cancer and presented at the

Oncology Centre in Basra, with

ages ranging from 28 to 68

years old. Forty-five apparently

healthy females made up the

control group, with ages ranging

from25 to 70 years old. The

HHV-8 immunoglobulin G (IgG)

antibody detectionwas done

using an ELISAwith previously

stored sera. HHV-8was detected

in 31.1%of thewomenwithbreast

cancer, andastatistically significant

difference was determined. The

highest HHV-8 seropositivity

(17.8%) was seen in the

51–60 years old age group, and

significant differences were

found between the patient

and control groups with regard

to the different age groups.

Invasive ductal carcinoma

was the most common type

of breast malignancy in the

women, with the majority

of the patients classified as

stage II. The histopathological

types had a significant effect

on the outcome proportion

of the HHV-8 IgG antibodies.

Fourteen of breast cancer

patients with blood transfusion

histories, 6.7% were HHV-8 IgG

antibody positive, indicating a

significant difference. Diabetes

mellitus was determined to

be one risk factor associated

with a high seropositivity of

HHV-8, it occurred at a rate

of 13.3% among women

with breast cancer (p<0.05).

In addition, the sexual route

may be a significant risk

factor. However, the HHV-8

infected breast cancer patients

showed no statistically

significant association with the

coexistence of breast cancer

markers. Based on the results

of this study, female breast

cancer may be associated with

HHV-8. A blood transfusion,

diabetes mellitus and marriage

were found to be risk factors

for acquired HHV-8 infections

in breast cancer patients.

alturaihi@yahoo.com

JOURNAL OF ECOSYSTEM& ECOGRAPHY 2019, VOLUME 9 | DOI: 10.4172/2157-7625-C1-045

ACCEPTED ABSTRACTS