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43
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Serodiagnosis of
human herpesvirus 8
in women with breast
cancer
Dania Mudar Shakir
University of Basra, Iraq
H
uman herpesvirus 8 (HHV-8)
is a common virus in the
Mediterranean region. It has
been linked to a number of
malignancies, and it is believed
to be the causative agent
in certain cases. The aim of
this study was to evaluate
the distribution and possible
association between HHV-8
and breast carcinoma, and
to assess the risk factors
associated with an HHV-8
infection. A total of 90 blood
samples were collected. Forty-
five of these patients were
recently diagnosed with breast
cancer and presented at the
Oncology Centre in Basra, with
ages ranging from 28 to 68
years old. Forty-five apparently
healthy females made up the
control group, with ages ranging
from25 to 70 years old. The
HHV-8 immunoglobulin G (IgG)
antibody detectionwas done
using an ELISAwith previously
stored sera. HHV-8was detected
in 31.1%of thewomenwithbreast
cancer, andastatistically significant
difference was determined. The
highest HHV-8 seropositivity
(17.8%) was seen in the
51–60 years old age group, and
significant differences were
found between the patient
and control groups with regard
to the different age groups.
Invasive ductal carcinoma
was the most common type
of breast malignancy in the
women, with the majority
of the patients classified as
stage II. The histopathological
types had a significant effect
on the outcome proportion
of the HHV-8 IgG antibodies.
Fourteen of breast cancer
patients with blood transfusion
histories, 6.7% were HHV-8 IgG
antibody positive, indicating a
significant difference. Diabetes
mellitus was determined to
be one risk factor associated
with a high seropositivity of
HHV-8, it occurred at a rate
of 13.3% among women
with breast cancer (p<0.05).
In addition, the sexual route
may be a significant risk
factor. However, the HHV-8
infected breast cancer patients
showed no statistically
significant association with the
coexistence of breast cancer
markers. Based on the results
of this study, female breast
cancer may be associated with
HHV-8. A blood transfusion,
diabetes mellitus and marriage
were found to be risk factors
for acquired HHV-8 infections
in breast cancer patients.
alturaihi@yahoo.comJOURNAL OF ECOSYSTEM& ECOGRAPHY 2019, VOLUME 9 | DOI: 10.4172/2157-7625-C1-045
ACCEPTED ABSTRACTS