clinical-gastroentrology-2016_posters-accepted-abstracts

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Clinical Gastroenterology 2016

October 03-05, 2016

Volume 6, Issue 6(Suppl)

J Gastrointest Dig Syst

ISSN:2161-069X JGDS, an open access journal

conferenceseries

.com

October 03-05, 2016 Toronto, Canada

International Conference on

Clinical Gastroenterology & Hepatology

Lipidomic-based investigation into the regulatory effect of schisandrin B on palmitic acid level in

non-alcoholic steatotic livers

Hiu Yee Kwan, Tiejun Tong, Wang Fun Fong, Zhi-Ling Yu and Aiping Lu

Hong Kong Baptist University, China

chisandrin B (SchB) is one of the most abundant and bioactive dibenzocyclooctadiene derivatives found in the fruit of

Schisandra chinensis. Here, we investigated the potential therapeutic effects of SchB on non-alcoholic fatty-liver disease

(NAFLD). In lipidomic study, ingenuity pathway analysis has highlighted palmitate biosynthesis metabolic pathway in the

liver samples of SchB-treated high-fat-diet-(HFD)-fed mice. Further experiments showed that the SchB treatment reduced

expression and activity of fatty acid synthase, expressions of hepatic mature sterol regulatory element binding protein-1, tumor

necrosis factor-α and hepatic level of palmitic acid which is known to promote progression of steatosis to steatohepatitis.

Furthermore, the treatment also activated nuclear factor-erythroid-2-related factor 2 which is known to attenuate the

progression of NASH-related fibrosis. Interestingly, in fasting mice, a single high-dose SchB induced transient lipolysis and

increased the expressions of adipose triglyceride lipase and phospho-hormone sensitive lipase. The treatment also increased

the plasma cholesterol levels, 3-hydroxy-3-methylglutaryl-CoA reductase activity and reduced the hepatic low-density-

lipoprotein receptor expression in these mice. Our data not only suggested SchB as a potential therapeutic agent for NAFLD,

but also provided important information for a safe consumption of SchB, because SchB overdosed under fasting condition will

have adverse effects on lipid metabolism.

Evaluation of the impact of pre and post-transplant metabolic derangements on the neurological

complications following liver transplantation

Mohamed Mohamed Bassam Faek Mohamed Hashem

Cairo University, Egypt

eurologic complications after liver transplantation are a major source of morbidity and mortality and proper prediction

for those at risk may help in improving the outcome. The results of our study showed that severity of end stage liver

failure prior to transplantation might be the most common risk factor for the development of post-transplant neurological

complications and careful evaluation of other risk factors may be required for those patients in order to decrease the

incidence of complications. Still the use of tacrolimus is associated with risk of neurological complications and reduction or

discontinuation of tacrolimus lead to improvement of neurological complications. According to our study, electrolytes and

metabolic derangements are not risk factors for development of neurological complications. Although the risk of neurological

complications in our series is high but there was no impact on the survival.

J Gastrointest Dig Syst 2016, 6:6(Suppl)