29 / 29
Page 65
Volume 9
Journal of Obesity & Weight Loss Therapy
ISSN: 2165-7904
JOINT EVENT
Childhood Obesity 2019
Diabetes Conference 2019
March 18-19, 2019
&
3
rd
World Congress on
Diabetes and Obesity
12
th
International Conferences on
Childhood Obesity and Nutrition
March 18-19, 2019 | Rome, Italy
The exon 8 deletion polymorphism of the UCP2 gene is associated with severe obesity in a Saudi Arabian
case-control study
Yahia A Kaabi
Jazan University, Kingdom of Saudi Arabia
O
besity is a major health concern in Saudi Arabia. The Uncoupling protein 2 (UCP2) seems to play a major role
in regulation of human metabolism, therefore genetic polymorphisms in the UCP2 gene might contribute to
obesity in part of the world. The main objective of the current study was to establish whether 45-bp insertion (I)/
deletion (D) polymorphisms in Uncoupling protein 2 (UCP2) are associated with moderate and/or severe obesity in a
Saudi Arabian population. The aim of this study is to test the association between the UCP2 45-bp insertion/deletion
polymorphism and moderate or severe obesity in Saudi Arabian population. 151 male and female Saudi Arabian
volunteers from eastern province were participated in this study. They were divided as; non-obese, moderately
and severely obese. Genomic DNA was extracted from all subjects and subjected to UCP2 gene insertion/deletion
polymorphism genotyping using a standard PCR procedure. The overall frequency of the UCP2 45-bp insertion/
deletion genotypes was 58.3 %, 36.4 % and 5.3 % for the D/D, I/D and I/I genotypes respectively. The D/D genotype
was highly prevalent in the severely obese group (82.9 %) compared to non-obese (46.2 %) or moderately obese (53.3
%). In a dominant model, logistic regression analysis showed no significant association between the insertion allele
and moderate obesity (OR = 0.75, 95% CI: 0.35 - 1.59, P = 0.585), however, a strong inverse association was found
with severe obesity (OR= 0.18, 95% CI: 0.07 - 0.44, P = 0.0004). The study presented the frequency of the UCP2 45-
bp ins/del polymorphism in Saudis from eastern region. We also reported a strong association between the del/del
genotype and severe obesity in our population.
Keywords— Uncoupling protein 2, UCP2 insertion/deletion polymorphism, Obesity.
J Obes Weight Loss Ther 2019, Volume 9
DOI: 10.4172/2165-7904-C1-091