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Page 57
Volume 9
Journal of Obesity & Weight Loss Therapy
ISSN: 2165-7904
JOINT EVENT
Childhood Obesity 2019
Diabetes Conference 2019
March 18-19, 2019
&
3
rd
World Congress on
Diabetes and Obesity
12
th
International Conferences on
Childhood Obesity and Nutrition
March 18-19, 2019 | Rome, Italy
Handgrip strength identificates type 2 diabetes mellitus patients with higher fracture risk
Federica Bellone
University Hospital of Messina, Italy
P
atients suffering from type 2 diabetes mellitus (T2DM) show increased fracture risk in comparison with healthy
subjects. Bone mineral density (BMD), as measured by DXA, may be not enough to discriminate T2DM patients
with higher fracture risk. Our aim was to investigate whether handgrip strength may be associated with bone health
in T2DM patients. Anthropometric data and information about metabolic control and diabetic complications were
recorded. Handgrip strength by dynamometer, FRAX derived 10-years probability of major osteoporotic fractures
and hip fractures were also assessed. Bone evaluation was performed by a dual-energy X-ray absorptiometry (DXA)
densitometer at the lumbar spine (L1-L4) and at the femoral neck; based on specific software, the trabecular bone
score (TBS) was calculated. Lateral scan of thoracic and lumbar spine was assessed to investigate morphometric
vertebral fractures (Vfx). 29 patients (female 65%) [median age 67 (60 to 70)] with T2DM were considered.
Morphometric vertebral fractures were detected by DXA in 17% of patients without gender differences. The median
ten years probabilities of fractures were 8.1% and 2.3% as for major osteoporotic or hip fracture respectively. Median
femoral neck T-score value [-1.1 SD (-1.8 to -0.5)] was indicative of osteopenia, while lumbar spine T-score was
observed even in the normal range [-0.8 SD (-1.5 to -0.1)]. TBS was positively associated with BMD at lumbar
spine and femoral neck. Median handgrip strength value was 22.3 kg (18.9 to 31.3). At multiple regression analysis,
handgrip strength predicted both lumbar (β=0.009, SE 0.0034, p=0.01) and femoral neck BMD values (β=0.006, SE
0.002, p=0.01). Age (β=-0.008, SE 0.002, p=0.007) and handgrip strength (β=0.01, SE 0.002, p=0.0001) were also
independently associated with TBS score, after correcting for mean HbA1c values and time since T2DM diagnosis.
These findings suggest that handgrip strength may be a reliable tool to investigate bone fragility in T2DM.
J Obes Weight Loss Ther 2019, Volume 9
DOI: 10.4172/2165-7904-C1-091