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Journal of Gastrointestinal & Digestive System | ISSN: 2161-069X | Volume: 8
&
&
October 29-30, 2018 | San Francisco, USA
International Conference on
Gastrointestinal Cancer and Therapeutics
4
th
World Congress on
Digestive & Metabolic Diseases
26
th
Annual Congress on
Cancer Science and Targeted Therapies
Momordica charantia
mitigates hepatic injury following adjuvant treatment with antiretroviral drugs in
diabetic and non-diabetic animal models
Offor U
1
, Naidu ECS
and
Azu OO
1,2
1
University of KwaZulu-Natal, South Africa
2
University of Namibia, Namibia
H
epatogenous diabetes and hepatoxicity traced to highly active antiretroviral therapy (HAART) is a significant threat to the
health of mankind and calls for urgent attention.
Momordica charantia
(
M. charantia
) is a medicinal plant, used in Ayurveda
for treating various diseases, including diabetes mellitus. This study investigated the possible protective effect of
M. charantia
against
HAART and streptozotocin STZ induced hepatoxicity. 78 adult male Sprague Dawley rats were divided into two groups (non-diabetic
and diabetic) and treated according to protocols. Diabetes was induced with streptozotocin (STZ) by intraperitoneal injection (45
mg/kg body weight). The animals were euthanized on the tenth week with livers removed for examination and blood obtained via
cardiac puncture and centrifuged to collect the serums. Blood glucose levels (BGL) were consistently and significantly raised in all
groups not receiving the adjuvant
M. charantia
(p<0.05). Treatment with
M. charantia
reverses the increase in BGL to near normal.
Markers of liver injury assayed showed a significant increase (p<0.05) in AST, ALP and ALT levels in diabetic groups not receiving
M. charantia
. Adjuvant HAART and
M. charantia
caused significant declines in the liver enzymes (p<0.05). Serum GGT was not
markedly altered. Treatment with
M. charantia
significantly restored liver enzymes elevations to near normal comparable to control.
Histopathological observations ranged from severe hepatocellular distortions, necrosis and massive fibrosis following treatment of
HAART in diabetic and non-diabetic groups.
M. charantia
did not show any sign of hepatotoxicity as judged from the histological
and biochemical observations.
ugochukwuoffor@yahoo.comJ Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C8-086