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Journal of Gastrointestinal & Digestive System | ISSN: 2161-069X | Volume: 8

October 29-30, 2018 | San Francisco, USA

International Conference on

Gastrointestinal Cancer and Therapeutics

World Congress on

Digestive & Metabolic Diseases

Annual Congress on

Cancer Science and Targeted Therapies

The potential role of gut microbiota in pancreatic disease: A systematic review

Robert Memba

Joan XXIII University Hospital, Spain

Background:

Several studies have suggested a link between microbiota imbalance and some gastrointestinal, inflammatory and

neoplastic diseases. However, the role in pancreatic diseases remains unclear. To evaluate the available evidence for pancreatic

diseases, we undertook a systematic review.

Methods:

OVIDMedline (1946 to 2017), EMBASE (1980 to 2017) and the Cochrane Central Register of Controlled Trials (CENTRAL

Issue 3, 2017) were searched for studies on microbiota in pancreatic disease. We also searched the reference lists of retrieved papers

and conference proceedings. We excluded animal studies, reviews, and case reports.

Results:

A total of 2,833 articles were retrieved. After screening and applying the exclusion criteria, 10 studies were included. Three

studies showed lower levels of

Bifidobacterium

Lactobacillus

and higher levels of

Enterobacteriaceae

in chronic pancreatitis. Two of

these studies were uncontrolled, and the third (controlled) study which compared patients with endocrine and exocrine insufficiency,

reported that Bacteroidetes levels were lower in those patients without diabetes, while Bifidobacteria levels were higher in those

without exocrine insufficiency. Only one study investigated acute pancreatitis, showing higher levels of Enterococcus and lower

levels of

Bifidobacterium

versus healthy participants. There was an overall association between pancreatic cancer and lower levels of

Neisseria elongate, Streptococcus

mitis and higher levels of

Porphyromonas gingivalis

and

Granulicatella adiacens

Conclusions:

Current evidence suggests a possible link between microbiota imbalance and pancreatic cancer. Regarding acute and

chronic pancreatitis, data are scarce, dysbiosis appears to be present in both conditions. However, further investigation is required to

confirm these findings and to explore therapeutic possibilities.

J Gastrointest Dig Syst 2018, Volume 8

DOI: 10.4172/2161-069X-C8-086