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Journal of Gastrointestinal & Digestive System | ISSN: 2161-069X | Volume: 8
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October 29-30, 2018 | San Francisco, USA
International Conference on
Gastrointestinal Cancer and Therapeutics
4
th
World Congress on
Digestive & Metabolic Diseases
26
th
Annual Congress on
Cancer Science and Targeted Therapies
Hormonal abnormalities in chronic hepatitis C patients
Ayfer Serin
and
Elmar Mammadov
Şişli Florence Nightingale Hospital, Liver Transplantation Unit, Turkey
T
rials have been performed on changes in hormonal profiles in alcohol-related chronic liver disease. In this presentation, we
will present our findings on hormonal changes in patients with HCV-related chronic liver diseases. The study group included
30 patients with chronic liver disease secondary to hepatitis C infection. Additionally, a control group was formed. We investigated
serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (T.TES), Free-testosterone (F.TES),
Estradiol (E2), Androstenedione (AND), Dehydroepiandrosterone (DHEA), Progesterone (PPOGES), Prolactin (PRL), and sex
hormone binding protein (SHGB), which were measured by radioimmunoassay and chemiluminescent immunoassay methods.
Serum F.TES levels in patients with HCV-related chronic liver diseases were found to be significantly lower than in the control group
(p=0.002). Serum fT3 and fT4 levels in patients with HCV-related cirrhosis were found to be lower than those in the control group
(p=0.04, p=0.02, respectively). Serum PROGES levels were higher in the both in patients HCV-related chronic liver diseases and with
HCV-related cirrhosis compared to the control group (p=0.01, p=0.04 respectively). It was concluded that the patients suffering from
HCV-related chronic liver disease present a degree of hormonal imbalance that will be discussed in the presentation.
ayferserin@gmail.comJ Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C8-086