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Journal of Gastrointestinal & Digestive System | ISSN: 2161-069X | Volume: 8
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&
October 29-30, 2018 | San Francisco, USA
International Conference on
Gastrointestinal Cancer and Therapeutics
4
th
World Congress on
Digestive & Metabolic Diseases
26
th
Annual Congress on
Cancer Science and Targeted Therapies
Characterizing CXCR3 in inflammatory bowel disease: Small molecule inhibition of CXCR3 attenuates
experimental model of Crohn’s disease
Caroline Nguyen
University of Colorado School of Medicine, Colorado
I
nflammatory bowel disease (IBD) is a group of disorders characterized by idiopathic chronic inflammation of the intestine. Though
IBD affects millions of individuals in the US and is responsible for billions of health care dollars, there is very limited treatment and
no cure for the disease. Previous investigators have implicated the importance of the chemokine receptor CXCR3 in the propagation
of IBD, as evidenced by the increased expression of its ligands in diseased tissue. Our work aims to discover the expression profile
of CXCR3 and its ligands CXCL9, CXCL10, and CXCL11 and whether a small molecule inhibitor of CXCR3, AM487, can attenuate
the murine model of Crohn’s disease, a subset of IBD. Mice were treated with the CXCR3 small molecule inhibitor AM487 in order
to evaluate the expression profile of CXCR3 and its ligands and the cytokine phenotype of the cells expressing CXCR3. CXCR3 is
expressed preferentially by inflammatory T cells in the gut, and these CXCR3+ T cells, and its ligands are significantly increased in
disease, at the site of inflammation. The small molecule inhibitor AM487 is capable of attenuating the severity of disease in the murine
model of Crohn’s disease. CXCR3+ T cells play an important role in potentiating inflammation in the gut. A better understanding
of its expression profile will allow for more specific and effective methods of treating Crohn’s disease. We show that small molecule
inhibition of CXCR3 is capable of mitigating disease severity in our model of IBD.
caroline.p.nguyen@ucdenver.eduJ Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C8-086