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Volume 2, Issue 4 (Suppl)
Breast Can Curr Res, an open access journal
Breast Pathology 2017
August 23-24, 2017
August 23-24, 2017 Toronto, Canada
4
th
World Congress on
Breast Pathology and Cancer Diagnosis
Novel targets in the peripheral blood mononuclear cells and circulating plasma differentiate poor
prognosis breast cancer subtypes
Sirin Adham
Sultan Qaboos University, Oman
C
irculating plasma and peripheral blood mononuclear (PBMCs) cells provide an informative snapshot of systemic
physiology state. The role of neuropilin-1 (
NRP-1
) and its interacting molecules was investigated in breast tumor tissue
however the clinical impact of their systemic levels was not fully evaluated. In this cross-sectional study, we found that
plasma
NRP-1
and placental growth factor (PlGF) were increased in advanced nodal and metastatic breast cancer compared
with locally advanced disease. Triple negative breast tissues expressed higher levels of both
NRP-1
and PLGF compared with
other subtypes. Furthermore, in PBMCs,
NRP-1
and its interacting molecules
SEMA4A
and
SNAI1
were significantly down
regulated in breast cancer patients compared with healthy controls.
SEMA4A
,
SNAI1
,
PLXNA1
and
VEGFR3
were inversely
expressed with disease stage, indicating protective role. Moreover, two signature molecules;
VEGFR3
and
PLXNA1
were
exclusively unregulated in PBMCs of Triple Negative Breast cancer (TNBC) cases, which underline the ability of PBMC
expression profiles to differentiate among tumor molecular subtypes. These molecules showed differential levels according to
patient’s age a notion which might impact therapeutic plan. Finally, this work supports the importance of
NRP-1
-associated
molecules present in the circulation to characterize poor prognosis breast cancer and emphasizes on their role as favorable
drug targets.
Biography
Sirin Adham has obtained her PhD degree in 2002 from University of Leon, Spain. She has worked as Post-doctoral Fellow at University of Waterloo and
University of Guelph, Canada from 2003 to 2009. From 2009 until present, she is working as an Assistant Professor at Sultan Qaboos University, Oman.
sadham@squ.edu.omSirin Adham, Breast Can Curr Res 2017, 2:4 (Suppl)
DOI: 10.4172/2572-4118-C1-008