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conferenceseries.com
Volume 2, Issue 4 (Suppl) Breast Can Curr Res, an open access journal Breast Pathology 2017
August 23-24, 2017
August 23-24, 2017 Toronto, Canada
4th World Congress on
Breast Pathology and Cancer Diagnosis
Maurizio Montella, Breast Can Curr Res 2017, 2:4 (Suppl)
DOI: 10.4172/2572-4118-C1-008
Diabetes, obesity and breast cancer prognosis in mediterranean women
Maurizio Montella
National Cancer Intitute G Pascale Foundation, Italy
Obesity and diabetes reached epidemic proportion and may be associated with breast cancer (BC) survival outcomes.
We therefore studied the association of obesity, diabetes and their combination (DM&Ob) with disease-free survival
and overall survival. Our study included 991 pre and post-women with non-metastatic BC treated with mastectomy
or breast-conserving surgery in two oncologic hospitals in Naples (Italy). Obesity was assessed as body mass index
>30kg/m2, while diabetes was categorized according to the American diabetes association guidelines. Patients and tumor
characteristics including staging and molecular subtyping were evaluated using the Kruskal-Wallis H test for age, the
Mantel-Haenszel linear-by-linear association chi-square test for trends for the ordered categorical variables and chi-
square test for other categorical variables. Patient outcomes were analyzed in terms of both disease-free survival (DFS;
with local, contralateral and distant disease recurrence and secondary primary tumors and death from any cause defined
as event) and overall survival (OS; with death from any cause defined as event). There were a total of 137 recurrences
after five years, mostly in the DM and Ob group (28%). There were no significant differences in DFS or OS between obese
only (p=0.4 and 0.7, respectively) or diabetes only (p=0.8 and 0.5, respectively) compared to those without obesity or
without diabetes. The fully adjusted multivariate Cox regression analyses showed a direct association of DM and Ob with
DFS (HR=2.54, 95% CI 1.30-4.98) and with OS (HR=2.30; 95% CI 1.02-5.17), suggesting that the co-presence of diabetes
and obesity had an independent and strong prognostic value.
Biography
Maurizio Montella is a Medical Doctor having Specialization in Epidemiology and Public Health. He is the Head of Department of Epidemiology of the National
Cancer Institute of Naples. He works with the Ministry of Health on low glycemic index diet, exercise and vitamin D to reduce breast cancer recurrence (DEDiCa):
design of a clinical trial. He has 282 published papers with citation 6896 and H-Index 46.