breast-pathology-2017-scientifictracks-abstracts

18 / 26

Page 46
Notes:
conferenceseries.com
Volume 2, Issue 4 (Suppl) Breast Can Curr Res, an open access journal Breast Pathology 2017
August 23-24, 2017
August 23-24, 2017 Toronto, Canada
4th World Congress on
Breast Pathology and Cancer Diagnosis
MicroRNA-145 functions as a tumor suppressor by targeting matrix metalloproteinase 11 and Rab
GTPase family 27a in triple negative breast cancer
Feng Yan
Nanjing Medical University, China
Through increasing evidences have documented that microRNA-145 (miR-145) acts as a tumor suppressor in breast cancer,
its exact role in triple negative breast cancer (TNBC) remains poorly defined. In this study, the expression of miR-145
in human TNBC cells and samples from 30 patients was analyzed by stem-loop real-time PCR. We found that miR-145 was
significantly downregulated in TNBC tissues and cells. Upregulating miR-145 in HCC1937 cells dramatically suppressed cell
proliferation and induced G1 phase arrest, whereas MDA-MB-231 cells did not show growth inhibition. MiR-145 exhibited
inhibitory role in cell invasion through the post-transcriptional regulation of the novel targets MMP11 and Rab27a in TNBC
cells. Additionally, miR-145 silencing could be reversed by DAC. These results demonstrated that miR-145 plays inhibitory
role in TNBC malignancy by targeting MMP11 and Rab27a, which might be potential therapeutic and diagnostic targets for
TNBC.
Biography
Feng Yan is the Vice Director of Department of Clinical Laboratory in Nanjing Medical University Affiliated Cancer Hospital and Jiangsu Cancer Hospital. The
research works focus on the Bioanalytical Chemistry in laboratory medical diagnostics, particularly in detection of tumor markers and tumor cells. She has
published 42 papers in SCI journals.
Feng Yan, Breast Can Curr Res 2017, 2:4 (Suppl)
DOI: 10.4172/2572-4118-C1-008