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Volume 2, Issue 4 (Suppl) Breast Can Curr Res, an open access journal Breast Pathology 2017
August 23-24, 2017
August 23-24, 2017 Toronto, Canada
4th World Congress on
Breast Pathology and Cancer Diagnosis
Kaiso roles in racial disparity of TNBC prevalence and outcomes
Juliet M Daniel
McMaster University, Canada
Breast cancer (BC) is the most frequent female cancer and 2nd leading cause of female deaths worldwide. However although
BC death rates have significantly declined globally in the past 20 years, women of African ancestry (WAA) still have a
disproportionately high BC mortality rate despite a lower overall BC incidence rate than Caucasian women. Intriguingly, the
aggressive and often fatal BC subtype, triple negative breast cancer (TNBC), is most common in young WAA but the reason
for this racial disparity in TNBC prevalence and mortality is currently unknown. Nonetheless, mounting evidence hints at
genetic risk factors rather than socio-economic status as a cause for this racial disparity. Recently, increased expression of
the unique transcription factor Kaiso was found to correlate with basal/TNBCs, suggesting that Kaiso may play a role in
TNBC aggressiveness and racial disparity in WAA. Using tissue microarray and immunohistochemistry, we investigated
Kaiso expression in a cohort of WAA TNBC patient tissues from Barbados and Nigeria, and a multi-ethnic cohort from the
USA. We found a significant correlation between high Kaiso expression, the degree of African ancestry, and shorter metastasis-free
survival in WAA. Notably, when Kaiso is depleted in BC cells, the cells exhibit decreased TGF® signalling (a known promoter
of metastasis), and did not metastasize to lungs or liver in a mouse model of breast cancer. Collectively these data implicate
Kaiso in TNBC aggressiveness and racial disparity.
Biography
Juliet M Daniel obtained her PhD in 1994 from the University of British Columbia, Vancouver, and conducted her Post-doctoral studies at St. Jude Children’s
Research Hospital (Memphis) and Vanderbilt University (Nashville) in Tennessee, USA. She is a Professor and Cancer Biologist in the Dept. of Biology at
McMaster University in Hamilton, Ontario, Canada. He has mentored over 20 graduate students and postdoctoral fellows, and published more than 30 articles
in reputed journals such as PLoS ONE, Oncotarget and Oncogenesis.
Juliet M Daniel, Breast Can Curr Res 2017, 2:4 (Suppl)
DOI: 10.4172/2572-4118-C1-008