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Volume 8
Journal of Biotechnology & Biomaterials
ISSN: 2155-952X
Biotech Congress 2018 & Enzymology 2018
March 05-07, 2018
JOINT EVENT
20
th
Global Congress on
Biotechnology
3
rd
International Conference on
Enzymology and Molecular Biology
&
March 05-07, 2018 London, UK
Computer aided screening of Mangrove ecosystem derived compound against Acetyl-cholinesterase
Shahid Ullah
Shenzhen University, China
A
lzheimer’s disease (AD) is considered as the most common type of dementia among older people. Almost 9 million
people are suffering from AD in china and increasing with the course of time. Currently many different herbs are used
for the treatment of AD including six Flavors Rehmannia Pills , Gastrodia and Uncaria Drink. It is been suggested that some
Acetyl-cholinesterase inhibitors induced molecular and cellular change that directly influence AD pathogeneses. In our study
literature search was perform to find Mangrove eco-system phytochemical structures by using Builder software implemented
in Molecular operating environment (MOE 2009). Acetyl-cholinesterase (PDB ID 1EVE) structure with bound ligand was
retrieved from protein data bank. Molecular docking was performed by triangular matcher placement method and rescore
by London dG parameter. The crystal structure has bound ligand which was active against acetyl-cholinesterase. It can be
concluded by docking analysis of different compounds that mangrove ecosystem compound may serve as good inhibitors
against Acetyl-cholinesterase
Biography
Shahid ullah is from Shenzhen University, China.
shahidullah@hust.edu.cnShahid Ullah, J Biotechnol Biomater 2018, Volume 8
DOI: 10.4172/2155-952X-C2-092