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conferenceseries.com
Volume 9 Journal of Biotechnology & Biomaterials
ISSN: 2155-952X Biomaterials 2019
February 25-26, 2019
February 25-26, 2019 | London, UK
4th Annual Conference and Expo on Biomaterials
Development of Biomimetic Scaffolds for Controlled Release of Bioactive Agent
Farah Alwani Azaman, Margaret E. Brennan Fournet, Maria del Mar Blanes Martinezand Declan M.Devine
Athlone Institute of Technology, Ireland
Osteogenic factors are a must have feature of bone regeneration scaffolds. Here we present a biomimetic delivery scaffold that
is directly translatable to clinical applications, integrating multiple intricate factors in an orthopaedic implant that is easy
to fabricate and adopt in the surgical setting. The straightforward preparation of a microporous bio-active scaffold designed for
sustained bio-agent release is presented. Chitosan, combined with osteoconductive bio-ceramics form the basis of the scaffold
architecture. The sustained release of growth factors (GF) for bone repair after trauma or non- union fractures is demonstrated.
An in situ crosslinking step provides a unique route to overcome the low GF stability and short half-life challenges under
physiological conditions. High initial burst release is prevented with effective prolonged delivery demonstrated. The scaffold
crosslinking reaction, mechanical properties and degradation profile characterization will be described. The bioactive bone
regeneration implant presents a substantial list of essential criteria including biocompatibility, biodegradability, micro/nano-
architectural physical cues and holds a great promise for therapeutic bone tissue repair.
Recent Publications:
1. Declan M. Devine, Eilish Hoctor, Jessica S. Hayes, Eoin Sheehan, Christopher H. Evans, “Extended release of proteins
following encapsulation in hydroxyapatite/chitosan composite scaffolds for bone tissue engineering applications”,
Materials Science & Engineering C, 1, 84, 281-28 (2018)
2. C.J.D. Bergmann, J.C.E. Odekerken, T.J.M. Welting, F. Jungwirth, D. Devine, L. Bouré, S. Zeiter,
3. L.W. Van Rhijn, R. Telle, H. Fischer, P.J. Emans. Calcium phosphate based three-dimensional cold plotted bone
scaffolds for critical size bone defects. BioMed Res Intern. 201, (2014)
4. J.A., Killion, S., Kehoe, L.M., Geever, D.M., Devine, E., Sheehan, D., Boyd, C.L., Higginbotham. Hydrogel/bioactive
glass composites for bone regeneration applications: synthesis and characterisation. Mat. Sci & Eng. C, 33(7), 2013,
4203-12.
5. MCanillas, GG de Lima, MA Rodríguez, MJDNugent, DMDevine, 2016. Bioactive composites fabricated by freezing-
thawing method for bone regeneration applications. J Polym Sci Part B: Polym Phys. 54(7):761-773.
Biography
The research team has extensive experience and participates in a number of international collaborator research activities in the bone tissue regeneration field. In
particular the team is focused on the development of variety of biomaterials which may be used to treat different ailments related to bone including, biomimetic bone
graft substitutes and biodegradable polymers with tailored properties and degradation profiles.
Farah Alwani Azaman et al., J Biotechnol Biomater 2019, Volume 9
DOI: 10.4172/2155-952X-C1-113