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.com
Volume 9
Journal of Biotechnology & Biomaterials
ISSN: 2155-952X
Biomaterials 2019
February 25-26, 2019
February 25-26, 2019 | London, UK
4
th
Annual Conference and Expo on
Biomaterials
Development of wearable sensor device using biodegradable microneedle patch
Eunjin An, Chang Yub Sung, Jung Dong Kim, Jung Hyun Bae, Keun Ho Lee, Moon Su Lee, Tae Hyung Kim, Seong Jin Kim, Geum Chae Jang, Yoonsik
Kang
and
Do Hyeon Jeong
Raphas Research Center, South Korea
T
he microneedle-mediated transdermal delivery systemhas been developed to provide minimal invasive self-administration
method. Droplet-born air blowing (DAB) method has great advantages in stability with precise dose control because DAB
provide quick manufacturing process with ambient temperature. Also, microneedle (MN) array is stamped on the skin, and
interstitial fluid (ISF) is obtained. MNs are designed to collect dermal interstitial fluid containing biomarkers without the risk
or pain needed for collecting blood. This study suggests the novel dissolving microneedle fabrication method, droplet-born
air blowing (DAB), which provide gentle temperature and fast manufacturing process with precise dose control. Microneedle
fabricated by DAB method. Briefly, biodegradable polymer such as HA (hyaluronic acid) were dissolved in water with active
ingredients. The mixture was dropped to a patch, and each droplet is shaped to the microneedle. The loaded amount of active
ingredients was analyzed by ELISA or HPLC/UV system. Skin permeability of microneedle was confirmed by OCT (optical
coherence tomography) and delivered amount into the skin was analyzed using Franz diffusion cell (Logan, FDC-6T). We
optimized the DAB process parameters and scaled up without applying any heat. Various ingredients were loaded within
microneedles approximately 100% compared to theoretical values independent of microneedle length. In vitro and ex vivo
studies using Franz diffusion cell showed excellent delivery efficiency compared to topical solution. In vivo OCT images clearly
showed that whole length of microneedles could penetrate into human skin. DAB technology suggests a way to solve the
problems of conventional molding method to fabricate dissolving microneedle. Based on the method, we have successfully
developed mass production system to manufacture microneedle-arrayed patch. We loaded lots of active ingredients with
precise dose control, and confirmed the delivery efficiency of labile ingredients within microneedles. Also, we can access to
biomarkers in dermis and future medical diagnostic and monitoring applications.
Recent Publications:
1. J DKim, MKim, HYang, K Lee and H Jung (2013) Droplet-born air blowing: novel dissolving microneedle fabrication.
Journal of Controlled Release 170(3):430-436.
2. S P Sullivan, D G Koutsonanos, M P Martin, J W Lee, V Zarnitsyn, S O Choi, N Murthy, R W Compans, I Skountzou
and M R Prausnitz (2010) Dissolving polymer microneedle patches for influenza vaccination. Nature Medicine
16:915–920
3. Kolluru C, Williams M, Chae J and Prausnitz M R (2019) Recruitment and collection of dermal interstitial fluid using
a microneedle patch. Advanced Healthcare Materials 1801262.
4. KimH K, Lee S H, Lee B Y, Kim S J, Sung C Y, Jang N K and Lee S (2018) A comparative study of dissolving hyaluronic
acid microneedles with trehalose and poly (vinyl pyrrolidone) for efficient peptide drug delivery. Biomaterials Science
6(10):2566-70.
5. Kim J H, Shin J U, Kim S H, Noh J Y, KimH R, Lee J and KimH K (2018) Successful transdermal allergen delivery and
allergen-specific immunotherapy using biodegradable microneedle patches. Biomaterials 150:38-48.
Biography
Eunjin An received her bachelor's degree in Department of Chemistry. Also, she received her Master´s degree in Department of Pharmacy from Duksung Women’s
University, Republic of Korea. Her research interests are biomaterial polymer materials and devices for effective drug delivery systems. And now her studying
microneedle patch for transdermal drug delivery system and wearable device at Raphas Co. Ltd. Raphas Co., Ltd. is engaged in the research and development of
cosmetics, medical devices and pharmaceuticals.
ejan@raphas.comEunjin An et al., J Biotechnol Biomater 2019, Volume 9
DOI: 10.4172/2155-952X-C1-113