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Volume 9
Journal of Biotechnology & Biomaterials
ISSN: 2155-952X
Biomaterials 2019
February 25-26, 2019
February 25-26, 2019 | London, UK
4
th
Annual Conference and Expo on
Biomaterials
Plasma electrolytic oxidation of titanium to biofunctionalize surfaces of ventricular assist devices
Eduardo GP Bock
IFSP, Brazil
V
entricular assist devices (VAD) are prescribed for congestive heart failure patients to stabilize their hemodynamics until
recovery or alternative therapy. The devices are essentially machined in commercially pure titanium (Ti cp) a biomaterial
capable of providing stable biological integration without compromising implant biofunctionality or patient well-being. The
promotion of biofunctional surfaces for VAD became possible through surface modification of VAD components in order to
improve the interface between biomaterial and assisted organ. A process was developed using plasma electrolytic oxidation
(PEO) technique to form a textured oxide layer in Ti cp. Scanning electron microscopy was used to certify the effectiveness
of texturing. A methodology was elaborated to assess the feasibility of endothelialization by in vitro cellular growth with
human umbilical vein endothelial cells (HUVEC). PEO process was able to provide a textured oxide coating in Ti cp; in which
the micrograph, scaffolding characteristics, has a proportional size to circulating blood cells and endothelial. Magnesium
incorporation has shown to be promising since extracellular membrane proteins of adherent cells need this element to exert
their function. In vitro procedure indicated endothelialization in modified surface as the HUVEC adhered three times more
on coated titanium oxide compared to the observed in the experiment with pure polished titanium. Endothelization in VAD
tends to occur in vivo during circulatory assistance; the presence of a thrombosis-resistant neointima at the interface between
implant/circulating blood aims to reduce the induction of heparin as anticoagulant thus assigning lower hemolysis due to
higher absorption of tensions shear per flow to the surface of VADs.
Recent Publications:
1. Bock E G P (2016) Review of introductory tests to in vivo evaluation, prototypes assembling and anatomical position
studies after five years. International Journal of Advanced Robotics and Automation 1:1-3.
2. Bock E G P et al. (2016) Left ventricle failure and blood flow estimation for centrifugal blood pumps. Journal of
Mechanics Engineering and Automation 6:162-166.
3. Lopes G, Bock E G P and Gómez L (2017) Numerical analyses for low Reynolds flow in a ventricular assist device.
Artificial Organs 41(6):E30-E40.
4. Uebelhart B et al. (2013) Study of a centrifugal blood pump in a mock loop system. Artificial Organs 37(11):946-949.
5. Bock E G P et al. (2011) Implantable centrifugal blood pump with dual impeller and double pivot bearing system:
electromechanical actuator, prototyping, and anatomical studies. Artificial Organs 35(5):437-442.
Biography
Eduardo G P Bock holds a Degree in Mechanical Engineering from Sao Judas Tadeu University (2003); a Masters (2007) and PhD (2011) in Mechanical Engineering
from the State University of Campinas – Unicamp, Brazil respectively. He is currently an Associate Professor (class D-IV) in the Laboratory of Bioengineering and
Biomaterials (BIOENG) of the Department of Mechanics at Federal Institute of Technology (IFSP), Sao Paulo (Brazil). He has experience in the field of biomedical
engineering with emphasis on bioengineering, working mainly in the following subjects: biomaterials, tribology, numerical simulation, artificial organs, artificial heart,
circulatory assistance, left ventricular assistance and extracorporeal circulation.
eduardobock@gmail.comEduardo GP Bock et al., J Biotechnol Biomater 2019, Volume 9
DOI: 10.4172/2155-952X-C1-113