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Volume 9
Journal of Biotechnology & Biomaterials
ISSN: 2155-952X
Biomaterials 2019
February 25-26, 2019
February 25-26, 2019 | London, UK
4
th
Annual Conference and Expo on
Biomaterials
Development of a novel chitosan based biocompatible and self-healing hydrogel for controlled release
of hydrophilic drug
Swati Sharma, Shere Afgan, Ashok Kumar, Deepak
and
Rajesh Kumar
Banaras Hindu University, India
S
mart polymeric hydrogels of chitosan and acryloyl-phenylalanine having potential of fast intrinsic shape memory properties
(self-healing), non-toxic, biocompatible with moderate mechanical strength have been developed. The hydrogel has been
formed by linking its network with flexible pendant side chains of chitosan and acryloyl-phenylalanine (exhibiting optimal
balance of hydrophilic and hydrophobic moieties). The non-toxic and biocompatible behavior of the synthesized chitosan based
hydrogel reveals its potential use towards the biomedical field. The side chain of hydrogel consists of amine and carboxylic acid
groups and these moieties allow non-covalent interactions (H-bonding) across its interface. Thus, synthesized hydrogel shows
very good self-healing property. Further, it has shown remarkable swelling (at different pH viz.- 2, 7, 9), cell viability (HEK-293
cells up to 200 μg/mL), cell proliferation, and controlled drug release and thus found multi-responsive.
orajesh@bhu.ac.inJ Biotechnol Biomater 2019, Volume 9
DOI: 10.4172/2155-952X-C1-113