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Volume 9
Journal of Biotechnology & Biomaterials
ISSN: 2155-952X
Biomaterials 2019
February 25-26, 2019
February 25-26, 2019 | London, UK
4
th
Annual Conference and Expo on
Biomaterials
3D-Printing of Bio ceramics for Bone Regeneration Applications
Rainer Gadow
University of Stuttgart, GerAbstract
B
one degradation and fractures represent a significant concern to human health and to the increased population life
expectancy. When such defects overcome a certain critical size, body induced autorepair cannot restore lost skeleton
functionality. Medical treatment involves bone grafting, a common surgical procedure with more than 2.0 million grafting
procedures performed worldwide each year. Autologous bone grafts are currently the golden standard treatment but are
associated with donor-site complications, risk of infection and size and shape limitations. Artificial scaffolds with tailored
geometry, porosity, architecture and composition present an alternative to autologous grafts and are excellent 3D templates to
provide structural support for ingrowth of the newly formed bone. The use of bioceramics like calcium phosphates (Hap,TCP)
or bioactive glasses for the regeneration of critical bone defects is intensively researched worldwide. The advantages of additive
manufacturing technology make it possible to process these ceramic materials into customized patient-specific implants. In
this work the process chain of powder-based inkjet-3D-printing is presented. This includes the production of bioceramic
suspensions from bioglass, calcium phosphates and composites and spray dry granulation to obtain flowable granulates.
3D-printing is performed from CAD-modelling to post-processing of the printed structures. Printed components are sintered
and characterized with respect to mechanical properties and in vitro biocompatibility. After sintering the scaffolds show high
porosity (about 70 %) and high surface roughness (Ra about 25 µm, Rz up to 200 µm) which is beneficial for the colonization
of bone cells. In vitro tests using MG-63 stem cells showed an effective growth of cells on the outer and inner surface of the
scaffolds and the formation of reinforcing secondary hydroxyapatite crystals.
rainer.gadow@ifkb.uni-stuttgart.deJ Biotechnol Biomater 2019, Volume 9
DOI: 10.4172/2155-952X-C1-113