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Volume 9
Journal of Biotechnology & Biomaterials
ISSN: 2155-952X
Biomaterials 2019
February 25-26, 2019
February 25-26, 2019 | London, UK
4
th
Annual Conference and Expo on
Biomaterials
Freeze-dried platelet as a natural source of essential growth factors for periodontium regeneration
Mohamed M Ammar
Future University in Egypt, Egypt
P
eriodontitis is a common disease that starts with gingival inflammation and may end with the formation of periodontal
pocket with loss of attachment and destruction of the supporting structures. This eventually leads to functional and esthetic
problems. Several limitations in the current treatment modalities restrict the reach for full periodontium regeneration. The
utilization of the science of tissue engineering and regenerative medicine offers the opportunity to overcome these limitations.
Platelet concentrates have been used to deliver a high dose of growth factors that can aid in the healing and regeneration of
wound defects. However, fresh prepared platelet concentrate has a shelf life of only 4-5 days and frozen platelet concentrate
loses a lot of its benefits. In addition, delivered growth factors have a short half-life in vivo (within hours) due to rapid clearance
which makes it difficult to maintain a therapeutic dose at the defect site throughout the healing period. Therefore, it was
hypothesized that incorporating freeze-dried platelets in high amounts with their load of many growth factors in a hydrogel
carrier can control their delivery and provide a sustained therapeutic dose for a longer period. In addition, an antimicrobial
easy-applicable hydrogel scaffold was used for better regeneration.
mohamed.abdelfattah@fue.edu.egJ Biotechnol Biomater 2019, Volume 9
DOI: 10.4172/2155-952X-C1-113