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Volume 7, Issue 2 (Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal Biomaterials 2017
March 27-28, 2017
2nd Annual Conference and Expo on
March 27-28, 2017 Madrid, Spain
Development of nanostructured biomaterials for bone and osteo-articular regeneration
Sybille Facca1,2 , Nadia Benkirane-Jessel3 and Arvind Argarwal 4
1Laboratoire ICube - CNRS, France
2Université de Strasbourg, France
3Laboratoire INSERM, France
4Florida International University, USA
During the last ten years, tissue engineering has merged with regenerative nanomedicine by combination, not only of new
biomaterials but also of stem cell technology and growth factors. The goal of this work was to use bone and cartilage engineering
as a model, in order to improve and to develop active and living nanostructured implants. We were interested in the development
of biomaterials (natural or synthetic), tridimensional (3D), transplantable for bone and cartilage diseases treatments, that are able
to induce more cellular differentiation and improved tissue regeneration. We have developed 3 types of nanostructured implants, (i)
titanium implants coated with hydroxyapatite and carbon nanotubes in order to improve osteoformation and osteoinduction around
arthroplasty implants; (ii) active capsules functionalized by growth factors and stems cells for bone induction (in vitro/in vivo) after
a bone defect; (iii) electrospun nanofibrous membranes functionalized by growth factors and (Osteoblasts/Chondrocytes) for bone
and cartilage regeneration, in vitro and in vivo.
Biography
Sybille Facca, MD, PhD, has her expertise in Orthopedic, Hand and Nerve Surgery as an Orthopedic Surgeon at Strasbourg Hospital University since 2007.
She was the first person focusing her research on bone and cartilage regeneration and drug delivery systems of bone cements or nanofibers membranes and
osteointegration of orthopaedic implants. Now, she is also focusing her research on tubes for nerve regeneration, microsurgery simulation or microanastomosis
mechanical properties and new design of wrist arthroplasty, in a biomechanical laboratory of Strasbourg University.
Sybille Facca et al, J Biotechnol Biomater 2017, 7:2 (Suppl)