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Volume 7, Issue 2 (Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal Biomaterials 2017
March 27-28, 2017
2nd Annual Conference and Expo on
March 27-28, 2017 Madrid, Spain
Modulation of cell behaviour on artificial materials by functional nano-topographies for applications in
regenerative medicine
Rodriguez I and Viela F
IMDEA Nanoscience Institute, Spain
C ells can react to synthetic surfaces with a wide way of responses which depend upon many factors, including chemical
composition of the surface and the physical properties of the bulk substrate material, including substrate stiffness, topography
feature size and geometry. It is now widely accepted that mechanical stimulus exerted onto cells by topographic cues can set off
specific physiological processes that ultimately dictate the cell behaviour and fate. Identifying the specific topographical cues that lead
to a specific cell behaviour, that is still an endeavour in biomaterial research for application areas impacting regenerative medicine or
tissue engineering. In this sense, there have been numerous approaches to develop materials with fine control of the topographical
features using micro and nanofabrication techniques. In our laboratory, we use polymer nanoimprinting to produce with nanoscale
precision and high reproducibility, cellular instructive micro and nano topographical environments. We specifically investigate the
response of progenitor neural stem cells to dense high aspect ratio polymer pillars on the micro and nano scale studies on cell viability,
morphology, cell spreading and migration indicating that high aspect ratio topographies impact dramatically the cytoskeleton
remodelling and distribution of the cellular tractions which in turn, gave rise to very distinctive cell behaviour. Nanosurface features
inspired on the moth eye topography have also been investigated as bactericidal biocompatible surfaces for bionic implants. This
surface has been demonstrated to be an effective bactericidal topography against Gram positive and Gram negative bacteria. At the
same time, the surface supported cell growth and did not influence the biological cellular responses.
Biography
Isabel Rodriguez is a Research Professor at IMDEA-Nanoscience. Her research interest is on areas related to the application of micro and nano fabrication
technologies on polymeric materials to construct functional surfaces. She currently works on the development of antibacterial surfaces and cell culture platforms
for cell biomechanical studies. She is also working on the development of multifunctional surfaces, particularly on those with super-hydrophobic, anti-reflective and
self-cleaning properties.
Rodriguez I et al, J Biotechnol Biomater 2017, 7:2 (Suppl)