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Journal of Clinical & Experimental Pathology | ISSN: 2161-0681 | Volume 8

December 03-04, 2018 | Chicago, USA

American Pathology and Oncology Research

International Congress on

Microbial Genetics and Molecular Microbiology

International Conference on

Co-delivery of anti-cancer drugs by combination therapy

Mahshid Jafari

Azad University of Science and Research, Iran

mong many cancer therapies, chemotherapy and photodynamic therapy (PDT) have been considered in this essay. For the

enhancement of the drug delivery, the use of the up-conversion material is taken into account. Under near-infrared (NIR)

excitation, up-conversion emits ultraviolet light. in the traditional PDT, injecting the photosensitizer (PS), as a drug, then using

illumination source like laser, light emitting diodes, arcing lamps and laser in order to active PS. Using up-conversion can help the

drug to penetrate in more depth of the tumor tissue, compared to the traditional PDT, and improve the efficiency of the drug and

finally the cancerous cell death. Additionally, we could assemble a core-shell nanoparticle to improve the chemotherapy as well as

PDT. In regard to this, we could conjugate doxorubicin (DOX) in the shell and then (PS) in the core in order to deliver two anti-

cancer. Then, the nanoparticle is PEGylated to overcome the dilemma of “protein corona”. Also, using folic acid (FA) for the cancerous

cell receptor, as a ligand, in the endocytosis-mediated process, we could guarantee the targeted therapy.

J Clin Exp Pathol 2018, Volume 8

DOI: 10.4172/2161-0681-C5-058