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conferenceseries.com
Volume 9 International Journal of Advancements in Technology
ISSN: 0976-4860 3D Printing 2018
March 19-20, 2018
March 19-20, 2018 | London, UK
2nd International Conference on
3D Printing Technology and Innovations
Implementation of entry-level bioprinters for biotechnological applications
Josefine Morgenstern, Carsten P Radtke and Jurgen Hubbuch
Karlsruhe Institute of Technology, Germany
Advances in printing technologies and the increasing availability of printable materials render 3D printing a promising
technology for biotechnological and pharmaceutical applications. By processing plastics or metals, 3D printing enables
biotech laboratories to develop custom-made lab equipment or even completely new tools through rapid prototyping.
However, the production and processing of biocompatible materials is required for the integrated printing of biologically
active components, such as proteins and cells. The 3D printing of biological or biocompatible materials, designated as
bioprinting, is nowadays almost exclusively applied for tissue engineering and regenerative medicine. One of the reasons
why bioprinting apart from tissue engineering is still a neglected methodology, is certainly the tedious process of becoming
a well-established and applicable technology. The commercially available bioprinters capable of printing the so called
bioinks and hydrogels are expensive and strongly targeted for the printing of cells and the provision of cell-friendly printing
environments. As a consequence, the access to these printers is strictly regulated and therefore impedes the application in non
cell-based investigations. Here, two entry-level bioprinters are presented, which have been developed by simple and affordable
technical modifications of conventional polymer printers. These are on the one hand a low-cost Fused-Filament-Fabrication
(FFF) 3D printer and on the other one hand a Digital Light Processing (DLP) system. The applicability of these bioprinting
systems is demonstrated by case studies using poly(ethylen glycol) diacrylate (PEGDA) as main hydrogel component and
enzymes as biological active component. Protein containing hydrogel structures are handled in multiwell plates enabling the
implementation of printed biomaterials in liquid handling station based high-throughput process development (HTPD). This
approach permits the investigation of hydrogels and their surrounding liquid phase for biological applications. The presented
entry-level concept combining bioprinting and HTPD is capable of accelerating the development of bio-synthetic hybrid
materials and their processing into functional three-dimensional objects.
Biography
Josefine Morgenstern is a Postdoctoral Researcher at Karlsruhe Institute of Technology, Germany. She has completed her Diploma and PhD at the same institute.
She is mainly interested in printing technologies and materials for biotechnological applications.
Josefine Morgenstern et al., Int J Adv Technol 2018, Volume 9
DOI: 10.4172/0976-4860-C1-002