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Page 85
Volume 7, Issue 6 (Suppl)
J Biotechnol Biomater, an open access journal
ISSN: 2155-952X
World Biotechnology 2017
December 04-05, 2017
2
nd
World Biotechnology Congress
December 04-05, 2017 | Sao Paulo, Brazil
Technological innovation against arbovirosis: Development of bioinsecticide against the mosquito
Aedes
aegypti
Fabiola Nunes
Federal University of Paraiba, Brazil
R
ecently, several emerging and reemerging arboviruses have caused concern around the world. The
Aedes aegypti
mosquito is the
vector of dengue, urban yellow fever, chikungunya and zika. Dengue is the most common arboviruses in the world, affecting
more than 2.5 billion people a year. On the other hand, the zika virus brought an alarming fact since it was linked to babies born with
microcephaly. Currently, Brazil is experiencing an outbreak of wild yellow fever in several regions of the country, which brings out
the fear of the return of urban yellow fever. The most efficient way to combat all these diseases is through the control of the mosquito
vector. This is mainly done by chemical insecticides, despite the emergence of resistance. In this sense, the search for new, safe and
effective insecticides is necessary. Our research group has explored the biotechnological potential of natural products, especially the
Agave sisalana
. Preliminary studies showed that the
A. sisalana
crude extract has important larvicidal activity against
Ae. aegypti
.
Through flow cytometry and histopathology, we observed that exposure to the crude extract of
A. sisalana
caused the necrosis of
hemocytes of the exposed larvae, besides lysis of the intestinal cells and the peritrophic membrane. These results show the potential
of
A. sisalana
as rawmaterial for the production of an insecticide that helps control emerging and reemerging arboviruses transmitted
by
Aedes aegypti.
fabiola@cbiotec.ufpb.brJ Biotechnol Biomater 2017, 7:6 (Suppl)
DOI: 10.4172/2155-952X-C1-086